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Dr. Macrene's Cosmetic Classification of Skin Aging*

Fine Line & Wrinkles Appearance – fine and coarse lines on face and neck.

Laxity Appearance – sagging skin, such as folds around the mouth and marionette lines, jowels, and loss of firmness to the neck.

Uneven Complexion – loss of luster in the undereye area, upper lip, and cheeks.

Uneven Skin Tone – appearance of age blotches and blemishes.

Loss of Radiance – ruddy appearance on the nose, chin, and eventually the rest of the face.

Textural Changes – appearance of roughness and unevenness which worsens over time.

Decrease in Luminosity – dullness to skin which worsens over time.

* Alexiades-Armenakas M.R., Dover J.S., Arndt K.A. The spectrum of laser resurfacing: non-ablative, fractional and ablative laser resurfacing. J Amer Acad Dermatol 2008 May; 58(5): 719-740

37 Actives provides the most potent proven ingredients to address each category of cosmetic skin aging actively combined in a single cream.  Independent testing by an esteemed laboratory confirmed clinical results for each category by objective quantitative measurements of the appearance of wrinkles, appearance of blotches and skin tone.