Macrene Actives High Performance Eye Cream
High Performance Eye Cream
High Performance Eye Cream
High Performance Eye Cream
Macrene Actives High Performance Eye Cream
Macrene Actives Eye Cream
Macrene Actives High Performance Eye Cream

High Performance Eye Cream

Regular price $135.00
Regular price Sale price $135.00
MoisturizingMoisturizing
FirmingFirming
Anti-WrinkleAnti-Wrinkle
IlluminatingIlluminating

Complete Skincare Around the Eyes


High Performance Eye Cream Formulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist & Research Scientist

A complete clinical treatment for the most revealing area of the face — 38 plant actives, peptides, and hyaluronic acid in one clean, vegan, fragrance-free formula.

The eye area ages differently than the rest of the face — thinner skin, constant movement, and a unique circulatory vulnerability that drives dark circles and puffiness. Dr. Alexiades formulated this cream specifically for that biology, building a 38-active system around the precise mechanisms that make the eye area so difficult to treat. Scientifically proven and dermatologist-tested to illuminate, depuff, and visibly reduce the appearance of fine lines and wrinkles.


Key Actives

Palmitoyl hexapeptide-12 — A targeted firming peptide clinically validated for the eye area, signaling collagen and elastin synthesis to visibly lift, firm, and smooth the delicate skin around the eye with consistent use.

Caffeine — The most clinically supported active for under-eye circles and puffiness. Caffeine constricts blood vessels, reducing the pooling of hemoglobin pigment that causes dark circles, while its anti-inflammatory properties visibly reduce morning puffiness and fluid retention.

Hydrolyzed hyaluronic acid — Broken down to its smallest molecular weight for maximum penetration into the thin skin of the eye area, delivering deep, sustained hydration that plumps fine lines and restores suppleness where the skin is most vulnerable to dehydration.

Full amino acid complex — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring the barrier integrity and softness that the eye area loses first with age.

Cocoa seed butter, jojoba esters & hydrogenated olive oil — A trio of plant-derived emollients and lipids that deeply nourish and reinforce the skin barrier without heaviness, restoring the suppleness and elasticity that thin eye area skin requires.

Squalane — A lightweight, skin-identical lipid that absorbs instantly and locks moisture in without occlusion, making it ideal for the eye area where heavier emollients can cause milia.

Eight-plant antioxidant shield — rosemary, coffee seed, yerba mate, sunflower, rice bran — A comprehensive botanical antioxidant system targeting the oxidative stress and chronic low-grade inflammation that drive accelerated aging, pigmentation, and loss of resilience specifically in the periorbital area.

Bisabolol & tocopherol — Botanical soothing and vitamin E antioxidant support to calm the chronic inflammation that contributes to both dark circles and visible aging around the eye.

Gluconolactone & calcium gluconate — A polyhydroxy acid pairing that gently resurfaces and brightens the eye area without the irritation risk of AHAs, improving skin texture, tone, and radiance while strengthening barrier function.

Sodium PCA & sodium lactate — Skin-identical humectants from the natural moisturizing factor that bind water within the skin layers, sustaining hydration long after application.

The Formulation Standard

Clean. Vegan. Fragrance-free. Every ingredient chosen with the knowledge that the eye area is the most sensitive skin on the face — and the most unforgiving of irritation. There are no shortcuts in this formula and no filler ingredients. Every one of the 38 plant actives earns its place against a specific mechanism of eye area aging.

What You Will See

Immediately: Visibly brighter, more awake eyes with reduced puffiness and a smoother, more hydrated appearance around the eye contour.

With regular use: Measurably reduced dark circles, visibly softened fine lines and crow's feet, firmer and more elastic skin around the eye area, and a sustained luminosity that reflects genuinely healthier periorbital skin over time.

active INGREDIENTS

  • Wrinkle Reducers: Peptides and Microencapsulated Hyaluronic Acids
  • Skin Calmers: Bisabolol, Coffee, Yerba Mate Tea, Feverfew Extracts
  • Anti-Oxidants: Resveratrol, Vitamins C & E, Edelweiss Extract
  • Rejuvenators: Plankton, Red and Blue Algae, Microalgae, Micrococcus, Arabidopsis Extracts
  • Rewinders: Mushroom Extract, Red Algae, Plant Polyphenols and Sterols, Resveratrol
  • Defenders: Squalane, Sunflower Extract, Plant Cholesterol and Phosphatidylcholine
  • Depuffers: Caffeine, Coffee Seed, Yerba Mate Tea, Feverfew and Cacao Extracts

ALL INGREDIENTS

Water (Aqua), Glycerin¹, Hydrogenated Ethylhexyl Olivate¹, Stearic Acid¹, Cetearyl Alcohol¹, Theobroma Cacao (Cocoa) Seed Butter¹, Cetyl Alcohol¹, Hydrogenated Coco-Glycerides¹, Jojoba Esters¹, Sorbitan Stearate, Palmitoyl Hexapeptide-12, Hydrolyzed Hyaluronic Acid, Rosmarinus Officinalis (Rosemary) Leaf Extract¹, Coffea Robusta Seed Extract¹²³, Ilex Paraguariensis Leaf Extract¹², Helianthus Annuus (Sunflower) Seed Extract¹, Oryza Sativa (Rice) Bran Extract¹, Hydrogenated Olive Oil Unsaponifiables¹³, Squalane¹²³, Sodium Lactate, Proline¹, Bisabolol¹, Tocopherol, Aspartic Acid, Glycine, Alanine, Serine, Valine¹, Isoleucine¹, Threonine¹, Histidine¹, Phenylalanine Arginine¹, Caffeine¹, Calcium Gluconate¹³, Gluconolactone¹³, Sodium Phytate¹, Alcohol¹, Hydrogenated Lecithin³, PCA¹, Sodium PCA¹, Sodium Benzoate³, Sodium Stearoyl Glutamate¹, Hydroxypropyl Methylcellulose Stearoxy Ether, Sodium Methyl Stearoyl Taurate, Limonene, Sodium Hydroxide.

¹Plant-Derived • ²USDA-Certified Organic • ³Third Party-Certified

FORMULATED WITHOUT

Gluten
Parabens
Phthalates
Sulfates
Fragrance
Acrylate
Propylene-Glycol
Mineral Oil
Petrolatum
Animal Byproducts
Mica
Talc
Silicone

HOW TO USE

Apply the DR. MACRENE actives High Performance Eye Cream twice daily around the eyes, after cleansing. Gently massage and spread using circling motions.

USDA Certified Organic Ingredients • Plant-Based • Cruelty-Free • Vegan • Non-Comedogenic • Packaged in Glass • Made in USA

CLINICAL RESULTS

*From an 8-week trial with 27 subjects, ages 37-68.

100%

said skin was smoother + tighter

98%

said under eyes were less puffy

98%

said dark circles were brighter

93%

saw reduced signs of fatigue around the eyes

BEFORE BEFORE
AFTER 8 WEEKS AFTER 8 WEEKS

DR. MACRENE actives

38

Highly potent, plant-derived actives in this product.

MA37™

Powered by patented multi-active technology.

"I was excited to try [this] after seeing Holstein name it the "best, best, best." A little goes a long way and instantly leaves my skin feeling dewy and hydrated. My biggest concern is fine lines, which practically disappeared."

Kristen Nichols, Who What Wear Editor