Frequently Asked Questions

You can select your preferred shipping method from the dropdown menu in your cart during checkout. For full details, please visit our Shipping & Returns Policy.

Orders placed before 12:00 PM Eastern Time (ET) on business days will ship the same day. Orders placed after 12:00 PM ET will ship the next business day. Thank you for shopping with us!

We want you to be completely satisfied with your order. If for any reason you are not, we gladly accept returns of unopened, unused, or defective products within 30 days of receipt.

All returns must be in original sealed packaging to be eligible for a refund or exchange. In your return package, please include a note with the reason for return.

Need a return shipping label? Simply email us at contact@macreneactives.com, and our customer service team will be happy to assist. Please allow 7-10 days for your return to be processed.

Visit our Ask Dr. Macrene page for answers to frequently asked questions. If you still have questions, feel free to reach out to us at contact@macreneactives.com.

Yes! We offer 2 complimentary samples with every order. You can choose from the available options at checkout—just click the “+” symbol in your cart to add the samples of your choice to your order.

We ship throughout the United States, including all 50 states, and internationally. For international orders, shipping rates will be calculated at checkout based on destination.

Orders can be canceled as long as their status is "in process." Once an order is marked as "shipped," it can no longer be canceled.

You can reach our team by emailing contact@macreneactives.com. We're happy to help!

Yes! We use packaging made from recycled materials. Learn more about our commitment to sustainability here.

Many of our products meet vegetarian, vegan, and gluten-free standards. If you have specific concerns or dietary restrictions, feel free to email us directly at contact@macreneactives.com—we’re here to help!

No worries—just email us at contact@macreneactives.com and we’ll assist you with placing your order.

Our products are designed to integrate seamlessly with other skincare products. For best results, cleanse with DR. MACRENE actives Cleanser, pat dry, apply the High Performance Face Cream first, let it absorb, and then layer anything else on top.

Any sunscreen you love will do.. Apply it as your final step 15 minutes before sun exposure and reapply every two hours.

Absolutely! Use all MACRENE actives products (except Tinted Moisturizer and Concealer) both morning and night for best results.

Use a small amount to the bone around the eyes. Gently feather it outward with your fingers to help with puffiness and dark circles.

Nope! We’re completely fragrance-free. Any scent you notice comes naturally from our active botanical ingredients.

The Extra Rich version has higher concentrations of actives and added ingredients like blue algae, jojoba and coconut extract for deeper hydration. It’s ideal if you have very dry skin.

Our entire line is safe and made with USDA Certified Organic Ingredients. Clean, effective, and science-backed.

Yes! Dr. Macrene formulated our products with sensitive skin in mind — including her own rosacea. You’ll likely see reduced redness and calmer skin with continued use.

1. Cleanse with lukewarm water and our High Performance Cleanser
   
2. Apply High Performance Face Cream (or High Performance Face Cream, Extra Rich)
   
3. Follow with the High Performance Serum
   
4. Dab High Performance Eye Cream around the eye area
   
5. Apply High Performance Neck & Décolletage Treatment
   
6. (Optional) Use High Performance Tinted Moisturizer/Concealer
   
7. Finish with High Performance Lip Filler

Yes, we do offer samples of the Tinted Moisturizer at checkout! We highly recommend selecting a sample with your purchase so you can try it first before opening the full-size bottle.

At this time, we do not offer samples of the Lip Filler—but rest assured, it’s packed with powerhouse ingredients including hyaluronic acid, peptides, ceramides, and 20 nourishing plant-based oils. It’s a true treatment product, and we’re confident you’ll love the results!

You don’t need one — our Serum has powerful anti-aging benefits. But if you do use retinol, apply it after our products at night and wear sunscreen during the day.

We don’t — and that’s intentional. Dr. Macrene recommends minimal exfoliation. Let our actives do the work and save harsher treatments for occasional use or professional peels.

Silicones provide that smooth, luxurious finish. They’re safe and effective. While we’ve removed them from skincare, we’re still working on a plant-based alternative for our makeup products.

Yes! It covers dark circles beautifully and treats the skin at the same time. Use a lighter shade if you want a brightening effect.

They adapt to your skin tone and reflect your natural light. The pigments are hand-selected by Dr. Macrene for a luminous, even finish that suits a wide range of complexions.

It contains mineral sun blockers like Titanium and Zinc Oxide, which helps protect your skin from the sun. However, we still recommend using a dedicated SPF for full sun protection.

Different areas, different needs! This treatment targets sagging, crepey skin, and sun damage specific to the neck and chest. The High Performance Face Cream focuses on facial skin protection and rejuvenation.

Apply the Cream first, then the Serum. Our liposome-based delivery system ensures the actives are absorbed and sealed in for longer-lasting benefits.

Yes! Each formula is packed with scientifically studied, organically farmed ingredients and thoroughly tested in small batches. The Cleanser alone has 20+ active ingredients to nourish and balance your skin.

It depends on your usage, but:

• 30ml = about 6 weeks
  

15ml = about 2–4 weeks A little goes a long way!

• Cream: Hydrates, soothes, and protects against aging and pollutants.
  
• Serum: Firms, lifts, and helps with skin tone and elasticity. They’re great alone — even better together.

No — we keep it clean, simple, and essential-oil-free.

Yes! Check out the Luxury Minis on our site. They’re perfect for trying or traveling.

Absolutely! The High Performance Lip Filler is formulated with deeply nourishing ingredients like Coconut Oil, Ceramides, Shea Butter, Squalene, and Plant Octyl Lipids to combat chapping. It also helps smooth the appearance of fine lines on the lips for a healthier, fuller look.

The High Performance Concealer contains adaptive pigments that blend seamlessly with your skin tone. For a brightening effect—especially under the eyes—we recommend choosing a shade lighter than your Tinted Moisturizer.

You may store the products in the refrigerator, but it’s not necessary—just keep them at room temperature below 80°F and away from steamy environments like bathrooms. Shelf life is three years unopened and one year after opening. Even after opening, the potency of active ingredients remains stable over time.

Yes, MACRENE actives products can be used alongside other skincare. For best results, apply our High Performance Face Cream first and allow it to absorb before layering additional products. The Face Cream is designed to be used all over the face, including around the eyes, both morning and night.

Absolutely. The High Performance Face Serum is lightweight yet powerful, delivering hydration, soothing benefits, and firming action—making it an excellent moisturizing option.

No. The High Performance Concealer is non-acnegenic and free from Talc and Mica—common irritants in other formulations. While it covers without causing breakouts, please note it is not an acne treatment.

A few of our products contain small, plant-derived amounts of caffeine to reduce puffiness and under-eye circles. These low doses help constrict broken capillaries and reduce redness, and also deliver antioxidant benefits—without irritation.

Our formulas use a blend of larger-size hyaluronic acid molecules, which have been shown to increase skin thickness without causing inflammation. In fact, our products are anti-inflammatory and help soothe sensitive skin.

Yes! It contains micro-encapsulated hyaluronic acid to deliver volume, peptides to smooth fine lines, ceramides for healing, and 20 therapeutic oils to protect and restore lip health—visibly reducing lines over time.

Our skincare is effective for all genders and skin types. For acne-prone skin, Dr. Alexiades recommends the High Performance Cleanser and Serum. The Cleanser includes Niacinamide and Vitamin B complexes to reduce acne and inflammation, while the Serum features plant extracts that combat adult acne. Use both twice daily for optimal results.

The Lip Filler is not a gloss—it's a treatment. Packed with hyaluronic acid spheres and peptides, it works over time to volumize and smooth lips. With consistent use (twice daily), you'll typically see visible results within two weeks. Shake well before each use.

Products are good for three to four years from the manufacturing date (unopened) and one year from the date of opening. If you’re unsure about a specific item, we can check the batch number to confirm.

Yes, a mild tingling sensation upon application is completely normal. It indicates that the active ingredients are beginning to take effect. This should subside quickly and should not cause discomfort or irritation.

No, the Eye Mask is designed for single use only. Once the mask has been fully activated, it should not be reused.

Apply your Eye Cream first, followed by the Eye Mask. The mask is best used as the second-to-last step in your skincare routine—just before applying Tinted Moisturizer and Concealer.

You can gently apply the remaining serum around the eye area, including above and around the brows, while the mask is in place.

The tray can be rinsed and placed in your recycling bin. The mask is made of biodegradable bio-cellulose with biodegradable cotton liners. However, the tray itself is not biodegradable. Despite extensive efforts, a biodegradable alternative for the tray has not yet been found but remains a priority for us.