Dr. Macrene Alexiades MD PhD Spotify Podcast

Introduction to Dr Macrene Alexiades MD PhD Podcast

Episode 1: Holistic Approach to Skin Health


Dr. Macrene Alexiades, MD PhD, dermatologist and scientist, provides an overview of the skin and its aging process. She emphasizes the importance of understanding the skin as an organ and the need to protect, restore, and maintain its health. Dr. Macrene discusses the structure of the skin, including the different types of cells and layers, and explains how UV exposure can cause damage to the skin. She highlights the role of DNA repair and antioxidants in preventing and repairing skin damage. Dr. Macrene also touches on the connection between skin aging and skin cancer, and the importance of a holistic approach to skin health.


skin, aging, organ, protection, restoration, maintenance, UV exposure, DNA repair, antioxidants, skin cancer


00:00 Understanding the Skin as an Organ

21:22 The Role of UV Exposure in Skin Aging

32:48 The Importance of DNA Repair and Antioxidants

38:33 Protecting and Restoring the Skin

45:19 Skin Health: Beyond Vanity


Episode 2: Free Radicals & Antioxidants


In this podcast episode, Dr. Macrene Alexiades discusses the damage that occurs to the skin due to free radicals and the importance of antioxidants in protecting and repairing the skin. Free radicals are highly reactive molecules that can cause damage to proteins, lipids, and DNA in the skin. This damage can lead to skin aging and potentially skin cancer. Antioxidants work by neutralizing free radicals and preventing them from causing further damage. Dr. Alexiades emphasizes the importance of a varied diet and the use of topical antioxidants to protect the skin. She also mentions the need for DNA repair enzymes as an additional layer of defense against mutations.


skin, free radicals, antioxidants, damage, protection, repair, skin aging, skin cancer, DNA repair


00:00 Introduction and Overview

02:26 Understanding Free Radicals

09:06 The Importance of Antioxidants

38:28 The Need for DNA Repair Enzymes

43:10 Conclusion


Free radicals can cause damage to proteins, lipids, and DNA in the skin, leading to skin aging and potentially skin cancer.

Antioxidants play a crucial role in neutralizing free radicals and protecting the skin from damage.

A varied diet rich in fruits and vegetables can provide antioxidants to the skin from the inside.

Topical application of antioxidants can further enhance the skin's defense against free radicals.

In addition to antioxidants, DNA repair enzymes are important for preventing mutations and maintaining skin health.


Episode 3: DNA Repair in Skin Longevity and Skin Aging


In this episode, Dr. Macrene Alexiades MD PhD discusses the importance of DNA repair in preventing skin damage and aging. She explains how DNA damage occurs due to free radicals and various environmental factors, such as UV radiation and pollution. Dr. Alexiades emphasizes the role of DNA replication and the need for accurate base pairing. She explores different types of DNA repair mechanisms, including direct reversal, excision repair, and post-replication repair. The podcast also delves into the use of DNA repair enzymes in skincare products and the benefits of liposomal delivery. In this conversation, Dr. Macrene Alexiades discusses the importance of DNA repair in skin health and the prevention of skin aging and cancer. She explains the different types of DNA damage and the various mechanisms of DNA repair. Dr. Alexiades also highlights the results of clinical studies that demonstrate the effectiveness of DNA repair enzymes in reducing DNA mutations, oncogene expression, and skin cancer incidence. Additionally, she discusses the impact of DNA repair on skin aging and the potential for ongoing repair even after the application of DNA repair enzymes has ceased.


DNA repair, skin health, free radicals, antioxidants, DNA replication, base pairing, DNA damage, UV radiation, pollution, skincare products, liposomal delivery, DNA repair, skin health, skin aging, skin cancer, UV damage, oncogenes, apoptosis, inflammation, photodynamic therapy, actinic keratosis, animal studies, telomere shortening, matrix metalloprotonases


·      DNA repair is crucial for preventing skin damage and aging caused by free radicals and environmental factors.

·      UV radiation, pollution, and chemical agents can cause DNA damage and mutations.

·      Different types of DNA repair mechanisms, such as direct reversal, excision repair, and post-replication repair, help maintain the integrity of the genetic code.

·      Topical products containing DNA repair enzymes, delivered through liposomal encapsulation, can enhance DNA repair in the skin.

·      Understanding DNA repair can lead to the development of effective skincare products for preventing skin cancer and premature aging. DNA repair enzymes can reduce DNA mutations and the incidence of skin cancer.

·      A multi-pronged approach, including DNA repair, is necessary for optimal skin health.

·      DNA repair enzymes can have a cascading effect on cellular responses, including inflammation and immunosuppression.

·      DNA repair can impact past damage and continue to repair DNA even after the application of repair enzymes has ceased.

·      DNA repair enzymes can improve skin aging by reducing wrinkles, laxity, pigmentation, and other signs of photoaging.


00:00 Introduction and Recap

04:17 Understanding DNA Damage and Aging

08:02 The Role of DNA Repair in Preventing Cancer

14:54 Exploring DNA Repair Mechanisms

27:14 The Benefits of Liposomal Delivery

29:59 The Importance of DNA Repair in Skin Health

34:59 The Need for a Multi-Pronged Approach

41:34 The Potential for Ongoing DNA Repair

45:46 The Impact of DNA Repair on Skin Aging