3.4 oz
3.4 oz
3.4 oz
3.4 oz
3.4 oz
3.4 oz
1.0 oz.
1.0 oz.
1.0 oz.
1.0 oz.
1.0 oz.

High Performance Neck and Décolletage Treatment

Regular price $315.00
Regular price Sale price $315.00
Anti-WrinkleAnti-Wrinkle
BrighteningBrightening
FirmingFirming
IlluminatingIlluminating

All-In-One Anti-Aging Neck Treatment

High Performance Neck & Décolletage Treatment Formulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist & Research Scientist

The neck and décolletage age faster than the face — and are almost always treated as an afterthought. This formula was built to correct that.

The skin of the neck and décolletage is thinner, has fewer sebaceous glands, is subjected to constant movement, and receives decades of sun exposure with a fraction of the skincare attention given to the face. The result is crepiness, loss of elasticity, brown spots, and a texture that no amount of facial treatment can address. Dr. Alexiades formulated this treatment specifically for that biology — a potent, peptide-rich active system targeting the precise mechanisms of neck and décolletage aging: elasticity loss, sun damage, uneven tone, and the fine lines and wrinkles that develop uniquely in this area.

Firm. Plump. Even. Revive.


Key Actives

Dipalmitoyl hydroxyproline — the elasticity peptide — A targeted peptide specifically validated for its ability to stimulate elastin synthesis and restore the elastic fiber network that gives neck skin its suppleness and recoil. Elasticity loss is the primary driver of crepiness and sagging in the neck and décolletage — this is the active that addresses it directly at the structural level.

Stabilized vitamin C (tetrahexyldecyl ascorbate) & resveratrol — sun damage reversal — An oil-soluble, stabilized vitamin C that penetrates where conventional vitamin C cannot, working synergistically with resveratrol to visibly brighten brown spots, even skin tone, and reverse the oxidative damage accumulated from years of UV exposure on the décolletage. The combination addresses both existing pigmentation and the inflammatory pathways that drive new spot formation.

Disodium acetyl glucosamine phosphate — A targeted brightening and exfoliating active that works at the surface to reduce the appearance of uneven pigmentation, refine skin texture, and improve the clarity and luminosity of sun-damaged skin.

Citrulline & citrullus lanatus (watermelon) extract — A clinically relevant pairing for skin barrier function and hydration. Citrulline is an amino acid precursor to arginine that supports the skin's own nitric oxide production, improving microcirculation and the delivery of actives to the treatment area. Watermelon extract amplifies the hydration and plumping effect for a visibly more supple, revived texture.

Kappaphycus alvarezii (red marine algae) extract — A clinically studied marine active with documented ability to firm and tone skin by supporting the extracellular matrix — the structural scaffolding that gives skin its density and resistance to crepiness.

Silver ear mushroom extract (Tremella fuciformis) — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration and visible plumping to the thin, dehydration-prone skin of the neck area.

Hydrolyzed hyaluronic acid — Small-molecule HA for maximum penetration, drawing moisture into the deeper layers of neck and décolletage skin where hydration is most needed and most rapidly lost.

Eight-plant antioxidant shield — Green tea, pomegranate, feverfew, yerba mate, green coffee, cocoa seed butter, edelweiss, microalgae, rosemary, sunflower, and rice bran form a comprehensive defense against the UV-induced and environmental oxidative stress that is the primary driver of brown spots, uneven tone, and accelerated aging in the décolletage.

Caffeine — Targets sluggish microcirculation in the neck area, reducing puffiness and the dull, congested appearance that compromised circulation creates in thinner skin.

Full amino acid complex — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring the barrier integrity and softness that neck and décolletage skin loses with age and sun exposure.

Olive-derived lipids, jojoba esters & squalane — A trio of structurally skin-identical emollients that replenish the lipid barrier, restore suppleness, and deliver the nourishing richness that the relatively sebaceous-gland-poor skin of the neck and décolletage cannot produce on its own.


What It Addresses

Crepiness & elasticity loss → dipalmitoyl hydroxyproline and red marine algae rebuild the elastic fiber network and extracellular matrix

Brown spots & sun damage → stabilized vitamin C, resveratrol, and disodium acetyl glucosamine phosphate brighten and reverse pigmentation

Fine lines & wrinkles → peptide system, multi-weight hyaluronic acid, and amino acid complex plump and smooth from within

Dullness & uneven tone → eight-plant antioxidant shield and brightening complex restore clarity and radiance

Dryness & crepey texture → olive-derived lipids, silver ear mushroom, and squalane nourish and restore suppleness


The Science Behind the Formula

The neck and décolletage present a clinical challenge that most skincare brands simply repurpose face cream to address. Dr. Alexiades did not. This formula was built around the specific biology of neck skin — its thinner structure, its elasticity dependence, its history of cumulative UV damage, and its unique need for both barrier repair and active treatment simultaneously. Dipalmitoyl hydroxyproline is the kind of targeted, mechanism-specific active that only appears in a formula when the formulator understood exactly what problem they were solving for.


How To Use

Apply to neck and décolletage morning and evening after serum, using upward strokes from the chest to the jawline. For the décolletage, smooth outward from the sternum. Use consistently — the elasticity and pigmentation changes this formula targets are built over time, and the results compound with continued use.


What You Will See

Immediately: Visibly more hydrated, smoother, and more supple neck and décolletage skin with a nourished, revived feel.

With regular use: Measurably improved elasticity and firmness, visibly reduced crepiness, brightened brown spots, more even skin tone, softened fine lines and wrinkles, and a sustained luminosity that reflects skin that has been genuinely treated — not just moisturized.


active INGREDIENTS

  • Firming Agents: Palmitoyl Hydroxproline Peptides High Concentration
  • Anti-Wrinkle: Hyaluronic Acids, Peptides, Proline
  • Anti-Oxidants: Green Tea Extract, Pomegranate Extract, Vitamins C and E
  • Anti-Red Blotches: Feverfew, Yerba Mate, Coffee Seed, Cocoa Seed Extracts, Bisabolol
  • Anti-Brown Blotches: Glucosamine, Ergothioneine, Arginine, Amino Acids
  • Rewinders: Kappaphycus Alvarezii (Red Algae) extract
  • Protectors: Resveratrol, Glucosamine, Histidine, Alanine
  • Illuminators: Vitamin C, Vitamin E, Coffee Seed Extract, Red Algae
  • Restorers: Citrullus lanatus (Watermelon) extract, Microalgae, Red Algae, Mushroom Extracts
  • Barrier Repair: Plant Cholesterol and Phosphatidylcholine, non-GMO Lecithin
  • Emollients / Moisturizers: Olive Oil Derivatives, Glycerin, Jojoba Esters, Sunflower Oil Derivatives, Sodium Lactate

ALL INGREDIENTS

Water, Hydrogenated Ethylhexyl Olivate¹³, Hydrogenated Olive Oil Unsaponifiables¹³, Glycerin¹, Helianthus annuus (Sunflower) Seed Oil Unsaponifiables¹, Jojoba Esters¹³, Dipalmitoyl Hydroxyproline¹³, Cetyl alcohol¹, Sorbitan Stearate, Sodium Hyaluronate, Camellia sinensis (Green Tea) Leaf Extract¹²³, Punica granatum (Pomegranate) Extract¹²³, Chyrsanthemum parthenium (Feverfew) Extract¹²³, Ilex paraguariensis (Yerba Mate) Leaf Extract¹²³, Coffea arabica (Coffee) Seed Extract¹²³, Theobroma cacao (Cocoa) Seed Butter¹²³, Tremella fuciformis sporocarp (Silver Ear Mushroom) Extract¹, Citrullus lanatus (Watermelon) Fruit Extract¹, Kappaphycus alvarezii (Red Algae) Extract¹, Scenedesmus rubescens (Microalgae) Extract¹, Resveratrol¹, Bisabolol¹, Tocopherol¹, Tetrahexyldecyl Ascorbate, Sodium Acetylated Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Disodium Acetyl Glucosamine Phosphate, Citrulline¹, Sodium Lactate, Arginine¹, Aspartic Acid¹, PCA¹, Glycine, Alanine, Serine, Valine¹, Proline¹, Threonine¹, Isoleucine¹, Histidine¹, Phenylalanine¹, Sodium PCA¹, Hydrogenated Lecithin¹³, Glyceryl Caprylate¹, Hydroxypropylmethylcellulose Stearoxy Ether, Sodium Phytate¹, Caprylhydroxyamic Acid¹, Sodium Benzoate, Sodium Methyl Stearoyl Taurate, Potassium Sorbate, Ethylhexylglycerin¹, Alcohol¹, Hydrogenated Phospatidylcholine¹³, Cholesterol¹, Tocopheryl Acetate.

¹Plant-Derived • ²USDA-Certified Organic • ³Third
Party-Certified

FORMULATED WITHOUT

Gluten
Parabens
Phthalates
Sulfates
Fragrance
Acrylate
Propylene-Glycol
Mineral Oil
Petrolatum
Animal Byproducts
Mica
Talc
Silicone

HOW TO USE

Use the DR. MACRENE actives High Performance Neck and Décolletage Treatment morning and evening, or if needed during the day. It can also function as a face serum.

Apply a hazelnut-sized amount to clean, damp skin of neck and décolletage and gently spread using circling motions.

Wait until the product has been absorbed by the skin completely before getting dressed. Use any excess product for the back of your hands to nourish skin and prevent visible signs of aging.

The Neck and Décolletage Treatment can also be used for other body areas that need tightening, lifting or have experienced sun damage.

USDA Certified Organic Ingredients • Plant-Based • Cruelty-Free • Vegan • Non-Comedogenic • Packaged in Glass • Made in USA

CLINICAL RESULTS

*From a 12-week trial of 31 subjects, ages 42-65.

87%

saw improvement in skin smoothness

79%

saw improvement in skin texture

76%

saw a visible reduction in fine lines + wrinkles

76%

saw improvement in skin firmness

DR. MACRENE actives

50

Highly potent, plant-derived actives in this product.

MA37™

Powered by patented multi-active technology.

"Few dermatologists understand how to tackle anti-aging skincare quite like Dr. Macrene, which is why [this] targeted treatment always has a place on our vanity. The botanical-rich formula uses 50 active ingredients to smooth, firm, and brighten the skin so that your existing damage is minimized and you’re protected against future signs of premature aging."

Hannah Baxter, Editor at Coveteur