High Performance Neck and Décolletage Treatment
All-In-One Anti-Aging Neck Treatment
High Performance Neck & Décolletage Treatment Formulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist & Research Scientist
The neck and décolletage age faster than the face — and are almost always treated as an afterthought. This formula was built to correct that.
The skin of the neck and décolletage is thinner, has fewer sebaceous glands, is subjected to constant movement, and receives decades of sun exposure with a fraction of the skincare attention given to the face. The result is crepiness, loss of elasticity, brown spots, and a texture that no amount of facial treatment can address. Dr. Alexiades formulated this treatment specifically for that biology — a potent, peptide-rich active system targeting the precise mechanisms of neck and décolletage aging: elasticity loss, sun damage, uneven tone, and the fine lines and wrinkles that develop uniquely in this area.
Firm. Plump. Even. Revive.
Key Actives
Dipalmitoyl hydroxyproline — the elasticity peptide — A targeted peptide specifically validated for its ability to stimulate elastin synthesis and restore the elastic fiber network that gives neck skin its suppleness and recoil. Elasticity loss is the primary driver of crepiness and sagging in the neck and décolletage — this is the active that addresses it directly at the structural level.
Stabilized vitamin C (tetrahexyldecyl ascorbate) & resveratrol — sun damage reversal — An oil-soluble, stabilized vitamin C that penetrates where conventional vitamin C cannot, working synergistically with resveratrol to visibly brighten brown spots, even skin tone, and reverse the oxidative damage accumulated from years of UV exposure on the décolletage. The combination addresses both existing pigmentation and the inflammatory pathways that drive new spot formation.
Disodium acetyl glucosamine phosphate — A targeted brightening and exfoliating active that works at the surface to reduce the appearance of uneven pigmentation, refine skin texture, and improve the clarity and luminosity of sun-damaged skin.
Citrulline & citrullus lanatus (watermelon) extract — A clinically relevant pairing for skin barrier function and hydration. Citrulline is an amino acid precursor to arginine that supports the skin's own nitric oxide production, improving microcirculation and the delivery of actives to the treatment area. Watermelon extract amplifies the hydration and plumping effect for a visibly more supple, revived texture.
Kappaphycus alvarezii (red marine algae) extract — A clinically studied marine active with documented ability to firm and tone skin by supporting the extracellular matrix — the structural scaffolding that gives skin its density and resistance to crepiness.
Silver ear mushroom extract (Tremella fuciformis) — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration and visible plumping to the thin, dehydration-prone skin of the neck area.
Hydrolyzed hyaluronic acid — Small-molecule HA for maximum penetration, drawing moisture into the deeper layers of neck and décolletage skin where hydration is most needed and most rapidly lost.
Eight-plant antioxidant shield — Green tea, pomegranate, feverfew, yerba mate, green coffee, cocoa seed butter, edelweiss, microalgae, rosemary, sunflower, and rice bran form a comprehensive defense against the UV-induced and environmental oxidative stress that is the primary driver of brown spots, uneven tone, and accelerated aging in the décolletage.
Caffeine — Targets sluggish microcirculation in the neck area, reducing puffiness and the dull, congested appearance that compromised circulation creates in thinner skin.
Full amino acid complex — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring the barrier integrity and softness that neck and décolletage skin loses with age and sun exposure.
Olive-derived lipids, jojoba esters & squalane — A trio of structurally skin-identical emollients that replenish the lipid barrier, restore suppleness, and deliver the nourishing richness that the relatively sebaceous-gland-poor skin of the neck and décolletage cannot produce on its own.
What It Addresses
Crepiness & elasticity loss → dipalmitoyl hydroxyproline and red marine algae rebuild the elastic fiber network and extracellular matrix
Brown spots & sun damage → stabilized vitamin C, resveratrol, and disodium acetyl glucosamine phosphate brighten and reverse pigmentation
Fine lines & wrinkles → peptide system, multi-weight hyaluronic acid, and amino acid complex plump and smooth from within
Dullness & uneven tone → eight-plant antioxidant shield and brightening complex restore clarity and radiance
Dryness & crepey texture → olive-derived lipids, silver ear mushroom, and squalane nourish and restore suppleness
The Science Behind the Formula
The neck and décolletage present a clinical challenge that most skincare brands simply repurpose face cream to address. Dr. Alexiades did not. This formula was built around the specific biology of neck skin — its thinner structure, its elasticity dependence, its history of cumulative UV damage, and its unique need for both barrier repair and active treatment simultaneously. Dipalmitoyl hydroxyproline is the kind of targeted, mechanism-specific active that only appears in a formula when the formulator understood exactly what problem they were solving for.
How To Use
Apply to neck and décolletage morning and evening after serum, using upward strokes from the chest to the jawline. For the décolletage, smooth outward from the sternum. Use consistently — the elasticity and pigmentation changes this formula targets are built over time, and the results compound with continued use.
What You Will See
Immediately: Visibly more hydrated, smoother, and more supple neck and décolletage skin with a nourished, revived feel.
With regular use: Measurably improved elasticity and firmness, visibly reduced crepiness, brightened brown spots, more even skin tone, softened fine lines and wrinkles, and a sustained luminosity that reflects skin that has been genuinely treated — not just moisturized.
active INGREDIENTS
active INGREDIENTS
ALL INGREDIENTS
ALL INGREDIENTS
FORMULATED WITHOUT
FORMULATED WITHOUT
HOW TO USE
HOW TO USE
CLINICAL RESULTS
*From a 12-week trial of 31 subjects, ages 42-65.
saw improvement in skin smoothness
saw improvement in skin texture
saw a visible reduction in fine lines + wrinkles
saw improvement in skin firmness
DR. MACRENE actives
Highly potent, plant-derived actives in this product.
Powered by patented multi-active technology.
"Few dermatologists understand how to tackle anti-aging skincare quite like Dr. Macrene, which is why [this] targeted treatment always has a place on our vanity. The botanical-rich formula uses 50 active ingredients to smooth, firm, and brighten the skin so that your existing damage is minimized and you’re protected against future signs of premature aging."
Hannah Baxter, Editor at Coveteur





















