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DR. MACRENE ALEXIADES, DERMATOLOGIST-SCIENTIST

Where the Clinic Meets the Jar

Every formula begins in the treatment room — developed by a dermatologist-scientist at the forefront of laser and regenerative medicine.

FATHER'S DAY | LIMITED TIME

New: Gift the Men's Essential Set

Three physician-formulated essentials. One effortless routine. $395 Value at $325 ($70 Savings)

Shop DR. MACRENE actives Best Sellers

Luxe / 1.0 oz.
1.0 oz.
1.0 oz.
Luxe / Light / 1.0 oz.
Luxe / 3.4 oz.
Macrene Actives High Performance Eye Cream
Luxe / 0.27 oz.
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You shouldn't need cosmetic procedures to have great skin.

Patented Dermatologic Science. 37 Classes of Plant Actives. Formulated by an MD/PhD.

With more active ingredients per formula than any comparable line, DR. MACRENE actives was built in a research laboratory by a dual board-certified dermatologist and Harvard scientist. Not to supplement clinical procedures. To replace the need for them.

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DR. MACRENE - Dermatologist Scientist

Macrene Alexiades, MD, PhD | Dual Board-Certified Dermatologist (US & EU) | Founder & Formulator

I believe you shouldn’t need cosmetic procedures to have great skin. For over 40 years, I’ve studied skin biology, genetics, and plant-based actives to create formulas that work at the source — addressing aging and skin health through dermatologic science, not trends or quick fixes.

I’m dual board-certified in dermatology in the US and EU and hold BA, MD and PhD degrees in medicine and genetics from Harvard. Every product is personally formulated to replace the need for cosmetic procedures, combining clean, effective science with decades of research.

Dermatological, Science-Backed Skincare

CLINICALLY PROVEN RESULTS

High Performance
Lip Filler

Science
96%

Agree it gives their lips a radiant glow

100%

Agree their lips look silkier after application

100%

Agree their lips feel more moisturized

93%

Agree their lips feel soft, smooth, and more hydrated

*In an 8-week clinical test of 27 subjects, ages 37-68
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Reviews

On her Skyros property, she has begun harvesting medicinal herbs that grow wild on the island—anti-inflammatory lemon verbena, antibacterial lemon balm, and skin-tightening linden — for the latest addition to DR. MACRENE actives.

Emma Elwick-Bates, Vogue

This eponymous line from New York City dermatologist Macrene Alexiades, MD, PhD, is known for doubling down on active ingredients, some of which are harvested from her own organic farm in Dutchess County, New York.

Dianna Mazzone Singh, allure

The High Performance Lip Filler is one I can't recommend enough, as it's a standout favorite from the product line. The formula provides a subtle plumping effect without the intense stinging that can often accompany a volume-boosting lip treatment.

Deanna Pai, Vanity Fair

DR. MACRENE actives delivers a minimalist, yet impactful approach to skincare, emphasizing the importance of a consistent routine with products like their High Performance Face Cream for skin restoration.

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