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Cleanser June

Once-a-Year Bundle: Best-Selling High Performance Cleanser + Serum for $260 ($290 value).

High Performance Cleanser

Specially formulated to maintain proper pH and microbiome, this cleanser will firm, tone, and smooth skin texture, while regulating sebum production and helping to reduce the appearance of fine lines and wrinkles. Rich with organic anti-aging antioxidants including green tea, aloe, olive leaf and mint extracts, it lathers into a foamthat cleans and treats skin while decreasing the appearance of blemishes, redness, and sun damage. Gentle enough for sensitive, irritable skin.

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Our Mission

Farm-to-Face: Medicinal botanicals sourced from Dr. Macrene's organic farm are extracted in her plant science laboratory followed by clinical trials on real patients in her Park Avenue dermatology research clinic and practice. Backed by plant science & dermatology research in her clinic, organic farm and lab, Dr. Macrene’s revolutionary formulas rejuvenate the skin with clean, active ingredients for visible restoration to take the place of cosmetic procedures. Organic, clean, scientifically proven and clinically tested plant derivatives are hand-made in small batches to deliver dermatologic grade efficacy, diminish signs of aging, and protect the skin from environmental pollutants and toxins. Experience real results that replenish, restore and rejuvenate skin to replace cosmetic procedures.

About Macrene Actives

High Performance Cleanser

Plant-Derived • Illuminating • Microbiome Balancing • PH Balancing • Hydration-Lock

“Dermatologist Dr. Macrene Alexiades launched MACRENE actives with the goal to ultimately replace cosmetic
procedures with skincare that achieves the same results.” -FORBES

“...eliminated skincare layering by creating a one-and-done cream with all the ingredients you’ll ever need.”

“...literally wrote the book on modern-day dermatology.”



The Texture and tone of my skin improved dramatically. I can go out of the house without makeup now and still get compliments.


Skin feels and looks so much better!


I have used this product for about 4 years I have very sensitive skin n I am unable to use most products but this cream has done wonders for my face I am not kidding I will use nothing else.


I have one word Amazing! Very happy with my choice.

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