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Skin Firming Action

Soothe, hydrate, firm, and even skin tone with this highly active, lightweight serum that will help to reduce the appearance of fine lines and wrinkles. Proven to lift and tighten crepiness while reducing blotches and evening skin tone, this serum repairs skin barrier while assisting in DNA restoration. Use after Macrene Actives High Performance Face Cream to seal in actives and achieve best results.

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Luxury Skincare

Our Mission

Backed by dermatology and plant science research in her clinic, organic farm and lab, Dr. Macrene’s revolutionary formulas rejuvenate the skin with clean, active ingredients for visible restoration to replace cosmetic procedures. Organic, clinically-tested plant derivatives are hand-made in small batches to deliver results, diminish signs of aging, and protect the skin from environmental pollutants and toxins.

About Macrene Actives

The Future of Skincare

Clean Dermatologic Science

"This modern approach to facial rejuvenation has replaced nip-and-tuck-surgeries"


“Dermatologist Dr. Macrene Alexiades launched MACRENE actives with the goal to ultimately replace cosmetic
procedures with skincare that achieves the same results.”

“...eliminated skincare layering by creating a one-and-done cream with all the ingredients you’ll ever need.”

“...literally wrote the book on modern-day dermatology.”



The Texture and tone of my skin improved dramatically. I can go out of the house without makeup now and still get compliments.


Skin feels and looks so much better!


I have used this product for about 4 years I have very sensitive skin n I am unable to use most products but this cream has done wonders for my face I am not kidding I will use nothing else.


I have one word Amazing! Very happy with my choice.

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