New Year's Gift: 50 ml High Performance Face Cream Extra Rich & Complimentary Luxury Mini High Performance Cleanser ($45 Value)
New Year's Bundle: 30 ml High Performance Face Cream Extra Rich & Full Size Cleanser for $295 ($340 Value)
Complimentary UPS Second Day Air Shipping on orders of $250+.*
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Winter Skincare

Restore Vitality with
High Performance Face Cream Extra Rich
Special Bundle and Gift with Purchase

Winter Skincare

Restore Vitality with
High Performance Face Cream Extra Rich
Special Bundle and Gift with Purchase

One-Step Skincare Solution

Ideal for dry and mature skin, this ultra-rich face cream is packed withVitamins C & E, red algae, andcoconut-based glyceridesto deliver a lush dose of hydration that’s ideal for night time or post-procedure needs. Proven to intensely hydrate while helping to reduce the appearance of fine lines, blemishes and redness, this extra rich cream smooths skin texture while repairing skin barrier and balance.

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Our Mission

Farm-to-Face: Medicinal botanicals sourced from Dr. Macrene's organic farm are extracted in her plant science laboratory followed by clinical trials on real patients in her Park Avenue dermatology research clinic and practice. Backed by plant science & dermatology research in her clinic, organic farm and lab, Dr. Macrene’s revolutionary formulas rejuvenate the skin with clean, active ingredients for visible restoration to take the place of cosmetic procedures. Organic, clean, scientifically-proven and clinically-tested plant derivatives are hand-made in small batches to deliver results, diminish signs of aging, and protect the skin from environmental pollutants and toxins. Experience real results that replenish, restore and rejuvenate skin to replace procedures.

About Macrene Actives

Dry Skin Relief

High Performance Face Cream Extra Rich

"This modern approach to facial rejuvenation has replaced nip-and-tuck-surgeries"


“Dermatologist Dr. Macrene Alexiades launched MACRENE actives with the goal to ultimately replace cosmetic
procedures with skincare that achieves the same results.”

“...eliminated skincare layering by creating a one-and-done cream with all the ingredients you’ll ever need.”

“...literally wrote the book on modern-day dermatology.”



The Texture and tone of my skin improved dramatically. I can go out of the house without makeup now and still get compliments.


Skin feels and looks so much better!


I have used this product for about 4 years I have very sensitive skin n I am unable to use most products but this cream has done wonders for my face I am not kidding I will use nothing else.


I have one word Amazing! Very happy with my choice.

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