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Face Serum July

NEVER BEFORE: Luxury Mini Neck and Décolletage Gift ($115 value) with purchase of $350 or more.

High Performance Face Serum

Soothe, hydrate, firm, and even skin tone with this highly active, lightweight serum that will help to reduce the appearance of fine lines and wrinkles. Proven to lift and tighten crepiness while reducing blotches and evening skin tone, this serum repairs skin barrier while assisting in DNA restoration. Use after Macrene Actives High Performance Face Cream to seal in actives and achieve best results.

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Our Mission

Farm-to-Face: Medicinal botanicals sourced from Dr. Macrene's organic farm are extracted in her plant science laboratory followed by clinical trials on real patients in her Park Avenue dermatology research clinic and practice. Backed by plant science & dermatology research in her clinic, organic farm and lab, Dr. Macrene’s revolutionary formulas rejuvenate the skin with clean, active ingredients for visible restoration to take the place of cosmetic procedures. Organic, clean, scientifically proven and clinically tested plant derivatives are hand-made in small batches to deliver dermatologic grade efficacy, diminish signs of aging, and protect the skin from environmental pollutants and toxins. Experience real results that replenish, restore and rejuvenate skin to replace cosmetic procedures.

About Macrene Actives

High Performance Face Serum

Firming | Illuminating | Anti-Wrinkle | Non-Acnegenic | Anti-Discolorations

“Dermatologist Dr. Macrene Alexiades launched MACRENE actives with the goal to ultimately replace cosmetic
procedures with skincare that achieves the same results.” -FORBES

“...eliminated skincare layering by creating a one-and-done cream with all the ingredients you’ll ever need.”

“...literally wrote the book on modern-day dermatology.”



The Texture and tone of my skin improved dramatically. I can go out of the house without makeup now and still get compliments.


Skin feels and looks so much better!


I have used this product for about 4 years I have very sensitive skin n I am unable to use most products but this cream has done wonders for my face I am not kidding I will use nothing else.


I have one word Amazing! Very happy with my choice.

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