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New Launch! SKYROS Collection High Performance Body Lotion & Cream

The first luxurious body line comprised of Grecian Medicinal Botanicals, featuring plant actives native to Dr. Macrene’s Island of Skyros.

Our Mission

Farm-to-Face: Medicinal botanicals sourced from Dr. Macrene's organic farms in Upstate New York and Greece are extracted in her plant science laboratory followed by clinical trials on real patients in her Park Avenue dermatology research clinic & practice. Backed by plant science & clinical dermatology research, Dr. Macrene’s revolutionary formulas help rejuvenate the skin with clean actives for visible restoration aimed to replace cosmetic procedures. Organic, clean, scientifically proven & clinically tested plant derivatives are hand-made in small batches to deliver dermatologic grade efficacy, help diminish signs of aging, & help protect the skin from the environment. Experience real results that replenish, restore & rejuvenate to replace cosmetic procedures.

About Macrene Actives

The Skyros Collection: Grecian Medicinal Botanicals

Discover the First Luxury Skincare based on the Powerful Plant Actives of the Greek Islands

“Dermatologist Dr. Macrene Alexiades launched MACRENE actives with the goal to ultimately replace cosmetic
procedures with skincare that achieves the same results.” -FORBES

“...eliminated skincare layering by creating a one-and-done cream with all the ingredients you’ll ever need.”

“...literally wrote the book on modern-day dermatology.”



The Texture and tone of my skin improved dramatically. I can go out of the house without makeup now and still get compliments.


Skin feels and looks so much better!


I have used this product for about 4 years I have very sensitive skin n I am unable to use most products but this cream has done wonders for my face I am not kidding I will use nothing else.


I have one word Amazing! Very happy with my choice.

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