GIFT WITH PURCHASE

High Performance Lip Filler, On Us!

The only MD PhD formulated needleless lip filler clinically proven to visibly boost fullness, smooth fine lines, and deeply hydrate. Complimentary on orders of $350 or more (a $135 value).

MOTHER'S DAY IS MAY 10th

The Gift of Radiant Skin, from Face to Body

Dr. Macrene's most beloved face, eye, and body essentials, together in an exclusive Mother's Day set, a $100 savings. Science meets nature, beautifully curated.

DR MACRENE'S STORY

The MD-PhD Dermatologist Who Wrote the Books on Skin

The first to coin the term actives and to pioneer peptides in skincare, the Derm-Scientist formulates with proven actives to restore natural beauty through a simple skincare routine instead of cosmetic procedures.

DR. MACRENE actives

You shouldn’t need cosmetic procedures to have great skin.

-

Clean Dermatologic Science Replacing Cosmetic Procedures

Shop DR. MACRENE actives Best Sellers

Luxe / 1.0 oz.
1.0 oz.
Healthy Skin Essentials Set

Healthy Skin Essentials Set

$345.00 $490.00
1.0 oz.
Luxe / Light / 1.0 oz.
Luxe / 3.4 oz.
Macrene Actives High Performance Eye Cream
Luxe / 0.27 oz.
The Mother's Ritual Set

The Mother's Ritual Set

$340.00 $445.00
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DR. MACRENE - Dermatologist Scientist

Macrene Alexiades, MD, PhD | Dual Board-Certified Dermatologist (US & EU) | Founder & Formulator

I believe you shouldn’t need cosmetic procedures to have great skin. For over 40 years, I’ve studied skin biology, genetics, and plant-based actives to create formulas that work at the source — addressing aging and skin health through dermatologic science, not trends or quick fixes.

I’m dual board-certified in dermatology in the US and EU and hold BA, MD and PhD degrees in medicine and genetics from Harvard. Every product is personally formulated to replace the need for cosmetic procedures, combining clean, effective science with decades of research.

Dermatological, Science-Backed Skincare

CLINICALLY PROVEN RESULTS

High Performance
Lip Filler

Science
96%

Agree it gives their lips a radiant glow

100%

Agree their lips look silkier after application

100%

Agree their lips feel more moisturized

93%

Agree their lips feel soft, smooth, and more hydrated

*In an 8-week clinical test of 27 subjects, ages 37-68
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In the Press

On her Skyros property, she has begun harvesting medicinal herbs that grow wild on the island—anti-inflammatory lemon verbena, antibacterial lemon balm, and skin-tightening linden — for the latest addition to DR. MACRENE actives.

Emma Elwick-Bates, Vogue

This eponymous line from New York City dermatologist Macrene Alexiades, MD, PhD, is known for doubling down on active ingredients, some of which are harvested from her own organic farm in Dutchess County, New York.

Dianna Mazzone Singh, allure

The High Performance Lip Filler is one I can't recommend enough, as it's a standout favorite from the product line. The formula provides a subtle plumping effect without the intense stinging that can often accompany a volume-boosting lip treatment.

Deanna Pai, Vanity Fair

DR. MACRENE actives delivers a minimalist, yet impactful approach to skincare, emphasizing the importance of a consistent routine with products like their High Performance Face Cream for skin restoration.

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DR. MACRENE actives Routine

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Customize, combine, and conquer your skincare goals with Dr. Macrene's scientifically advanced formulas.

Choose 3-5 products to create your bundle and enjoy 15% off.

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  • Enjoy 15% off every order, every time
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