Your Gifts This Month
Enjoy a complimentary Eye Mask with orders $295+. Spend $395+ to receive an Eye Mask and Face Serum (0.5 oz, $135 value).* Pair with Valentine's Duos for incredible value ✨
Valentine’s Duos: Lips, Eyes, Body
Dermatologically advanced formulas work better together for visible results across lips, eyes, and body skin, now at 15-25% offer.*
You shouldn’t need cosmetic procedures to have great skin.
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Clean Dermatologic Science Replacing Cosmetic Procedures
Shop DR. MACRENE actives Best Sellers
Macrene Alexiades, MD, PhD | Dual Board-Certified Dermatologist (US & EU) | Founder & Formulator
I believe you shouldn’t need cosmetic procedures to have great skin. For over 40 years, I’ve studied skin biology, genetics, and plant-based actives to create formulas that work at the source — addressing aging and skin health through dermatologic science, not trends or quick fixes.
I’m dual board-certified in dermatology in the US and EU and hold BA, MD and PhD degrees in medicine and genetics from Harvard. Every product is personally formulated to replace the need for cosmetic procedures, combining clean, effective science with decades of research.
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Dermatological, Science-Backed Skincare
High Performance
Lip Filler
Agree it gives their lips a radiant glow
Agree their lips look silkier after application
Agree their lips feel more moisturized
Agree their lips feel soft, smooth, and more hydrated
In the Press
On her Skyros property, she has begun harvesting medicinal herbs that grow wild on the island—anti-inflammatory lemon verbena, antibacterial lemon balm, and skin-tightening linden — for the latest addition to DR. MACRENE actives.
This eponymous line from New York City dermatologist Macrene Alexiades, MD, PhD, is known for doubling down on active ingredients, some of which are harvested from her own organic farm in Dutchess County, New York.
The High Performance Lip Filler is one I can't recommend enough, as it's a standout favorite from the product line. The formula provides a subtle plumping effect without the intense stinging that can often accompany a volume-boosting lip treatment.
DR. MACRENE actives delivers a minimalist, yet impactful approach to skincare, emphasizing the importance of a consistent routine with products like their High Performance Face Cream for skin restoration.
Build Your Own
DR. MACRENE actives Routine
Customize, combine, and conquer your skincare goals with Dr. Macrene's scientifically advanced formulas.
Choose 3-5 products to create your bundle and enjoy 15% off.
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