High Performance Face Serum

Skin Firming Action

High Performance Face Serum Formulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist & Research Scientist

The most advanced serum in the collection — 50 actives, one patented complex, every pathway of visible skin aging addressed.

This is the product Dr. Alexiades built in her quest to stave off plastic surgery. Not a single-ingredient serum with a compelling story — a comprehensive, 50-active treatment formula anchored by the patented MA37® peptide DNA repair complex, designed to address loss of firmness, uneven tone, dehydration, and environmental damage simultaneously and at the level of clinical precision.

Where most serums pick one mechanism and optimize for it, this one was formulated the way a dermatologist thinks: every pathway matters, every active earns its place, and the delivery system is engineered to make sure it all actually reaches the skin.

Key Actives

MA37® patented peptide DNA repair complex — Dr. Alexiades's proprietary innovation, available exclusively in DR. MACRENE actives formulas. Developed from her research background in cellular biology, this complex targets the skin's own DNA repair mechanisms to visibly firm, lift, and restore at a level no standard peptide ingredient can achieve. This is the scientific core of the entire collection.

Advanced firming and lifting peptide system — A multi-peptide architecture clinically shown to visibly firm and lift skin over time, signaling collagen and elastin synthesis and reinforcing the structural proteins that give skin its density and resilience.

Micro-encapsulated hyaluronic acids — Encapsulation technology controls the rate of delivery and ensures hyaluronic acid reaches deeper skin layers rather than evaporating at the surface — maximizing sustained hydration, plumping fine lines from within, and maintaining skin comfort throughout wear.

DNA-supporting enzymes — Work in concert with the MA37® complex to support the skin's natural repair mechanisms, addressing the cellular-level damage that accumulates from UV exposure, pollution, and biological aging.

Potent antioxidant complex — A broad-spectrum environmental defense system targeting free radical damage, oxidative stress, and the inflammatory pathways that drive premature aging, loss of radiance, and uneven tone.

Redness-reducing and brightening actives — Targeted ingredients that calm visible redness and unevenness while improving clarity, tone, and the overall luminosity of the skin surface.

The Delivery System

Fifty actives are only as effective as their ability to reach the skin. Dr. Alexiades built microencapsulation technology into the core of this formula to ensure controlled, sustained release — ingredients delivered at the right depth, at the right rate, without overwhelming the skin's barrier. The result is maximum efficacy without irritation, even for sensitive skin types.

How It Works With Your Routine

The High Performance Face Serum is the first step in Dr. Alexiades's two-product treatment system:

Serum → intensive correction, lifting, active delivery, and multi-pathway treatment

Cream → barrier reinforcement, structural support, and moisture lock

The serum opens the pathway. The cream seals and rebuilds. Used together, they address skin aging at every level — from cellular DNA repair to surface resilience.

The Science Behind the Formula

Fifty actives is not a marketing number — it is the result of a physician asking what it would take to address every visible dimension of skin aging in a single formula. Firmness, tone, hydration, environmental defense, redness, radiance — each requires a different mechanism, a different class of ingredient, and a different delivery strategy. Dr. Alexiades designed this serum the way she designs a clinical treatment protocol: comprehensively, precisely, and without compromise.

The MA37® complex is the anchor. Everything else is the supporting system that makes it perform.

What You Will See

Immediately: Visibly smoother, more hydrated, and more luminous skin with a lifted, refined appearance.

With regular use: Measurably firmer skin, improved tone and texture, reduced redness and unevenness, and a sustained clarity and resilience that reflects genuinely healthier skin at the cellular level.