Healthy-Looking Skin Starts Here
Enjoy a complimentary High Performance Cleanser 2 oz. (an $85 value) with any purchase of $295+.
Complimentary Standard Shipping
Now through December 17th, enjoy free standard shipping on all US orders.
Give the Gift of Derm-Science Skincare
Discover our new limited-edition gift sets, perfect for yourself or the skincare lover on your list.
Clean Dermatological
Science, Replacing Cosmetic Procedures
Shop DR. MACRENE actives Best Sellers
Dr. Macrene Alexiades, MD, PhD, Derm-Scientist
Trust your skin to the world's only Dermatologist-Scientist, MD, PhD, Founder, and Formulator.
With three degrees from Harvard in Medicine and Genetics and Double Board-Certified in Dermatology in the US and EU, Dr. Macrene is not only the world's #1 dermatologist for high-profile clients for over two decades, but her research on clean sustainable plant based solutions dates back over 40 years.
Dermatological, Science-Backed Skincare
High Performance
Lip Filler
Agree it gives their lips a radiant glow
Agree their lips look silkier after application
Agree their lips feel more moisturized
Agree their lips feel soft, smooth, and more hydrated
In the Press
On her Skyros property, she has begun harvesting medicinal herbs that grow wild on the island—anti-inflammatory lemon verbena, antibacterial lemon balm, and skin-tightening linden — for the latest addition to DR. MACRENE actives.
This eponymous line from New York City dermatologist Macrene Alexiades, MD, PhD, is known for doubling down on active ingredients, some of which are harvested from her own organic farm in Dutchess County, New York.
The High Performance Lip Filler is one I can't recommend enough, as it's a standout favorite from the product line. The formula provides a subtle plumping effect without the intense stinging that can often accompany a volume-boosting lip treatment.
DR. MACRENE actives delivers a minimalist, yet impactful approach to skincare, emphasizing the importance of a consistent routine with products like their High Performance Face Cream for skin restoration.
Shop by Skin Type
Build Your Own
DR. MACRENE actives Routine
Customize, combine, and conquer your skincare goals with Dr. Macrene's scientifically advanced formulas.
Choose 3-5 products to create your bundle and enjoy 15% off.
More from DR. MACRENE actives
Enjoy 15% Off
All Orders
with Auto-Replenish
- Enjoy 15% off every order, every time
- Choose any products to fit your routine
- Flexibility to pause, modify, or cancel anytime
Join the DR. MACRENE actives
Loyalty Program
- Earn 1 point for every $1 spent
- Earn 100 points when you follow us on Instagram
- Redeem $5 for every 100 points earned