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A Clean Revolution in Formula, Packaging & Manufacturing Practices



Derived from Nature. Backed by Science. Driven by Results.


MACRENE actives is the cleanest, scientifically active and clinically proven luxury skincare brand founded by world renowned dermatologist, scientist, and textbook author Dr. Macrene Alexiades, MD PhD FAAD.

The brand’s mission is to harness exceptional natural ingredients—a combination of potent plant actives sourced from the land and the sea—in order to create one-step topical skin care solutions to replace aesthetic procedures. 

Designed to achieve total skin health and youthful vitality by boosting skin quality, repairing stress, providing antioxidant support and fortifying integrity, among the over 50 organic actives in each formula, many are discovered on Dr. Macrene's organic farm. Packaged in glass, wood and uncoated paperboard printed with vegetal inks, MACRENE actives is always raising the bar in the industry for sustainable healthy skincare that is the best for you and for the planet.

Dr. Macrene's Organic Farm Q&A

Why did you start organic farming?

In my quest to raise the bar in clean skincare, I purchased the land and returned it to an agricultural property and protected wetlands. My goals: to grow organic botanical crops for MACRENE actives and to nurture a toxin-free natural wildlife zone in the Hudson Valley.

Which ingredients do you grow there?

A long list!!!! Arnica, 4 types of Sage, 4 types of Mint, 4 types of Lavender, 2 types of Rosemary, 4 types of Thyme, Eucalyptus, Echinacea, Calendula, Foxglove, Goji Berry, Borage, Ageratum, Epazote, Basil, Feverfew, Chamomile, Comfry, 4 types of Verbena, Bay leaf, Dill, Fennel, Garlic, Chrysanthemums, Tenacetum, Pennyroyal, Goldenrod, Milk Thistle, Grapes, Rhododendron, and many others that I will continue to chronicle.

Are there any special farming practices you use?

Organic practices and leave their fate to nature. While I have planted many varieties, the ones that resprout each year are the ones I study and utilize. I believe in growing what is meant to grow in the soil. My organic crops come back each year with natural rainwater and without any fertilizers or pesticides whatsoever. I believe in natural completely wild botanicals.

Any there any other notable bits of info that you want to share about your farm?

I have a log home on the property and live as close to nature as possible. We have wild coyotes, deer, owls, falcons, and in the streams and pond, black bass are teeming. I planted 40 trees this spring, including White Pine and Northern Spruce. My land is home to many bees because it is chemical free.

USDA Certified Organically Grown Ingredients

With our high-performance, plant-derived ingredients, skin transformation is possible. Clinically-tested solutions support a healthy, illuminated complexion and helps reduce the appearance of fine lines, sagging, and discoloration.

Plant-Derived Actives

From organic coffee seed to red algae, our toxin-free actives are packed with antioxidants that maintain skin barrier, moisturize, brighten, and boost texture. Naturally-occurring elements provide skin with raw materials needed to repair itself while defending DNA against aging.

Our Commitment

Our dedication to responsible social and environmental impacts begins at formula inception, and carried throughout each product’s lifespan. From organically-farmed ingredients, glass containers, paperboard, biodegradable inks and recycled packing materials, to hand-manufacture and charitable donations — each step plays a key role in the big picture of helping to preserve the planet and its inhabitants.