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About 37 Actives

After starting my Manhattan-based dermatology practice over 20-years ago, I set out to find a way to create an all-in-one, toxin-free anti-aging skin care solution for my patients.

"My patients and beauty editors who frequented my office found it impossible to keep up with the countless new skincare ingredients on the market and became worried about toxins.  

To layer products that can do everything would mean layering on toxic preservatives above the maximum allowable. It would also cost thousands of dollars and time in a day-to-day routine. That’s why I started my toxin-free one step plant-based skincare line."

With three Harvard University degrees, BA, MD, and PhD, I became Double Board-Certified in Dermatology in the U.S. and E.U. I also obtained a Fulbright in bioengineering and pioneered natural alternatives in agriculture. My scientific background and medical experience allowed me to formulate highly active, plant-based skincare.

I have been skincare expert for L’Oreal and Lancôme and Senior Editor for the Journal of Drugs in Dermatology, Editor of Dermatologic Surgery, JAMA Dermatology, Cosmetic Dermatology, Journal of Cosmetic and Laser Therapy, Journal of Laser Medicine and Surgery, and the Journal of the European Academy of Dermatology and Venereology, and am working on my 2500 page textbook, entitled, COSMETIC DERMATOLOGY. My academic and professional record of deeply-rooted research is what drives me to reach new heights in skincare. Recently, I was one of 100 people in the world selected for the Who's Who Lifetime Achievement Award.

I strived to raise the bar in skincare with plant-derived, toxin-free actives, eco-conscious packaging, and proven science. 37 Actives maintains 100% antioxidant activity up to six-months after opening the jar and maintains all its actives to three-years after manufacture, while using mainly plant-based preservatives. No other brand goes to the lengths of post-market testing of 37 Actives. Our science is unprecedented.
With my experience as an attending physician at the Yale New Haven Hospital at Yale University and the West Haven VA Hospital at Yale University, and Lenox Hill Hospital and my lab-based skincare dermatology practice, I have a unique and solid knowledge of both medicine and the beauty industry. It is this knowledge that led me to create 37 Actives skin care collection, the only product line on the market that is: free of parabens, phthalates, plastics, sulfates, mica, talc, animal and human-derived ingredients, and propylene glycol; in recyclable glass and paperboard using USDA-certified organic plant-derived ingredients; with post-market testing showing full activity and stability out to three years; and 100% Made in USA with US-sourced ingredients. I hope you enjoy my brainchild and the passion of my life, 37 Actives. 
Kind regards,
Dr. Macrene Alexiades

For more information or to schedule an interview with Dr. Macrene, please reach out to: