Clinical Study Results
MACRENE actives is rooted in science. Our products are rigorously tested by highly esteemed third party testing laboratories. Below you will find results from clinical studies performed.
What’s Behind MACRENE actives?
Dr. Macrene was inspired by scientific research work conducted over decades on ingredients that serve to protect and revitalize skin.
Macrene Alexiades MD PhD is dermatologist and molecular geneticist with a BA, MD and PhD from Harvard. She was motivated by the work of Drs. Thomas Lindahl, Paul Modrich, and Aziz Sancar who received the Nobel Prize in 2015 on DNA repair.
True to her commitment to replace cosmetic procedures with sea and plant-derived actives liposomally-delivered, MACRENE actives was created. Always ahead of the field, Dr. Macrene recognized the genius of scientific discoveries and developed and patented formulas to deliver over 55 plant-derived actives per pot that address all the aspects of skin health.
……………………………..
MACRENE actives High Performance Cream
Third-Party Clinical Laboratory Testing
MACRENE actives formulas were tested in clinical trials using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging at 4, 6, and 8 weeks of daily use. The results demonstrated statistically significant decreases in the appearance of fine lines and wrinkles, the appearance of cosmetic blotches, and improvement in texture and tone using objective clinical measures by computer analysis. Not one case of irritation was observed, demonstrating excellent
Revolutionary Post-Manufacture Testing
MACRENE actives is the first cosmetic cream to conduct post-market testing over time following manufacture. The antioxidant activity was shown to be maintained at nearly 100% up to 6 months after jar opening. HPLC analysis demonstrated that virtually all actives are maintained at original levels up to 3 years post-manufacture. Control products fell short on both these marks.
The formulas in MACRENE actives are the culmination of the very best scientific research from the lab proven to work on a clinical level so that just one jar of delivers results in all aspects of skin health, and systematically helps address the appearance of the many cosmetic changes of the skin over time, all this without toxins.
Cosmetic Wrinkle Appearance Reduction
When measurements taken after 4, 6 and 8 weeks of product use were compared with baseline measurements, there was:
- 8.5% improvement in the appearance of crow’s feet fine line / wrinkles after 4 weeks of product use;
- 17.0% improvement in the appearance of crow’s feet fine line / wrinkles after 6 weeks of product use; and
- 17.0% improvement in the appearance of crow’s feet fine line / wrinkles after 8 weeks of product use.
Appearance of Red Blotches Reduction
When measurements taken after 4, 6 and 8 weeks of product use were compared with baseline measurements, there was:
- 4.7% improvement in the appearance of red blotchy skin after 4 weeks of product use;
- 6.4% improvement in the appearance of red blotchy skin after 6 weeks of product use; and
- 10.9% improvement in the appearance of red blotchy skin after 8 weeks of product use.
Appearance of Brown Blotches Reduction
When images taken after 4, 6 and 8 weeks of product use were compared with baseline images, there was:
- 1.1% improvement in brown blotchy skin after 4 weeks of product use;
- 2.1% improvement in brown blotchy skin after 6 weeks of product use; and
- 3.4% improvement in brown blotchy skin after 8 weeks of product use.
Laboratory Results
Antioxidant Activity:
- Maintains 100% antioxidant activity 6 months after you open your jar.
- 100% of the actives are maintained at original levels out to 2 years.
- Competitors lose 50% of their antioxidant capability at 6 months and some creams have no actives, only preservative left at 1 year.
Case Studies - VOGUE - 12 Month of Beauty with Dr. Macrene
Before and After Photographs
VOGUE magazine conducted 12 Months of Beauty with Dr. Macrene, and editor Jancee Dunn applied MACRENE actives High Performance Cream, High Performance Serum and High Performance Neck and Décolletage Treatment for 12 months alongside non-surgical treatments. [left, before. right, after]
Ellenberg, C. VOGUE. 12 Months of Beauty with Dr. Macrene. Dec 20, 2017.
Published Clinical Trials
MACRENE actives was tested in an institutional review board approved clinical trial and published in the Journal of Drugs in Dermatology. 
Baseline (Left) and 6 Months (Right) Follow-Up Clinical Photographs Following Application of MACRENE actives High Performance Face Cream and Impact.
Alexiades, M. Randomized, Double-Blind, Split-Face Study Evaluating Fractional Ablative Erbium:YAG Laser-Mediated Trans-Epidermal Delivery of Cosmetic Actives and a Novel Acoustic Pressure Wave Ultrasound Technology for the Treatment of Skin Aging, Melasma, and Acne Scars. Journal of Drugs in Dermatology, 2015; 14(11):1191-1198.
……………………………..
MACRENE actives Neck and Décolletage Treatment Lotion
Third-Party Clinical Laboratory Testing
A third party testing laboratory assessed the High Performance Neck and Decolletage Treatment in clinical and consumer studies, using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging. The results demonstrated statistically significant improvements in the appearance of fine lines and wrinkles, brown discolorations, and radiance of the skin of the neck and chest at 4, 8 and 12 weeks:
4 week proven claims:8 week proven claims:100% of subjects reported that the product helped soothe the skin and left their skin feeling comfortable
80.65% of subjects reported that their fine lines and wrinkles are visibly improved.
80.65% of subjects reported that their neck and chest feels firmer.
87.10% of subjects reported improvement in the smoothness of the skin on the neck and chest.
90.32% of subjects reported the skin on the neck and chest felt more hydrated and moisturized instantly after application.
83.87% of subjects reported that their skin looks brighter and more radiant.
12 week proven claims:80.65% of subjects reported that their fine lines and wrinkles are visibly improved.
79.03% of subjects reported improvement in the texture of the skin on the neck and chest.
74.19% of subjects reported the skin on the neck and chest had less of a red or ruddy appearance.
77.42% of subjects reported that their skin tone looks more even.
80.65% of subjects reported that their skin looks younger.
80.65% of subjects reported that their neck and chest feels firmer.
87.10% of subjects agreed the smoothness of the skin on the neck and chest appeared improved and 80.65% of subjects agreed the appearance of their fine lines and wrinkles were visibly improved after using the product for 12 weeks
93.55% of subjects agreed that their skin felt softer and after 12 weeks.
90.32% of subjects agreed the skin on their neck and chest felt more hydrated and moisturized instantly after application of the product.
80.65% of subjects agreed that the product improved the way they feel about their skin after 4 weeks and after 12 weeks, 75.81% of subjects agreed that their results kept getting better after each week of use
83.87% of subjects reported Macrene Actives High Performance Neck and Décolletage treatment to be one of the best neck and décolletage lotions that they ever used, would recommend it to a friend or family member, and would continue to use it.
80.65% of subjects agreed that the product improved the way they feel about their skin after 4 weeks and after 12 weeks, 75.81% of subjects agreed that their results kept getting better after each week of use.
…………………….
MACRENE actives High Performance Tinted Moisturizer
Third-Party Clinical Laboratory Testing
A third party testing laboratory assessed MACRENE actives High Performance Tinted Moisturizer in clinical and consumer studies, using objective tools designed to quantitatively measure changes in the multiple categories of cosmetic skin aging. The results demonstrated statistically significant improvements in the appearance of fine lines and wrinkles, brown discolorations, and radiance of the skin of the face at 4, 8 and 12 weeks.
Clinical Results
93.94% of subjects demonstrated an improvement in the appearance of hyperpigmentation and age spots following application.
5.79% improvement in the appearance of global fine lines and wrinkles following application.
4.16% improvement in the appearance of global fine lines and wrinkles as compared to baseline following 12 weeks of product use.
2.59% improvement in the appearance of hyperpigmentation and age spots as compared to baseline following 12 weeks of product use.
75.76% of subjects reported that their skin tone looks more even.
90.91% of subjects reported that their skin feels softer.
100% of subjects reported that their skin looks natural.
100% of subjects reported it does not look like their wearing foundation.
78.79% of subjects reported that Macrene Actives High Performance Tinted Moisturizer is one of the best foundations that they have ever used.
90.91% of subjects reported that Macrene Actives High Performance Tinted Moisturizer soothed the skin.
90.91% of subjects reported that their skin looks brighter and more radiant.
81.82% of subjects reported seeing a minimization of pores.
84.85% of subjects reported that Macrene Actives High Performance Tinted Moisturizer covers blemishes.
93.94% of subjects reported that Macrene Actives High Performance Tinted Moisturizer did not make their skin breakout!
93.94% of subjects reported that they do not need to reapply throughout the day – it does not melt and wears all day!
87.88% of subjects reported that after the clinical study, they would recommend this product to a friend or family member.
Have more questions about Macrene Actives or your skincare routine?
Ask Dr. Macrene