Great skin rarely begins in the treatment chair. Dr. Macrene Alexiades, MD, PhD, recently spoke with Entertainment Tonight about the science behind lasting results — explaining why consistent daily care, not occasional intervention, is the foundation for healthy-looking skin. "As a scientist, I've spent my career studying the biology behind this, and none of it requires a syringe," she told ET.
Her Recommendations
1. Build on Three Fundamentals Dr. Macrene distills healthy skin to three essentials: a strong barrier, controlled inflammation, and consistent DNA and collagen support. Small, smart habits every day sustain all three far better than one dramatic gesture a month.
2. Look for a Complete Formula Skin ages through laxity, texture, pigmentation and redness at once, so no single ingredient is ever the whole answer. That principle shaped DR. MACRENE actives, built around a complex of active ingredients that she says visibly improves tone, texture and firmness.
3. Lay the Groundwork Before the Laser Energy-based devices are powerful tools, but they work best on well-supported skin. Dr. Macrene recommends topical peptides and barrier repair, along with daily SPF, before booking in-office treatments — so lasers are needed less often, not more.
4. Prioritize Sleep and Stress Management Cortisol takes a visible toll on skin, making rest and stress management two of the most underrated steps in any routine.
Read the Full Feature
Dr. Macrene's conversation with ET offers a clear, dermatologist-backed case for daily care — grounded in the same clinical authority and prevention-first philosophy behind DR. MACRENE actives. Read the full feature for her complete perspective on skincare, in-office treatments and daily habits.