DR. MACRENE actives, the scientifically active and clinically proven luxury plant-based skincare brand founded by world-renowned Dual EU–US Board-Certified Dermatologist and PhD Scientist Dr. Macrene Alexiades, MD, PhD, FAAD, FASLMS, pioneers the High Performance Eye Mask, a precision-engineered, dual-sided treatment delivery system designed to address multiple facial zones with a single application.
Pro Tip: FLIP EYE MASK OVER, PEEL THE SECOND COTTON LINER, AND USE IT TWICE!
Unlike conventional eye patches, the High Performance Eye Mask is intentionally constructed with two protective cotton liners—one on each side—each infused with serum, allowing the same biocellulose mask to be used sequentially for expanded anatomical coverage and maximum utilization of active ingredients. The mask is first applied under the eyes, then flipped by removing the second liner, enabling targeted treatment of the upper eye area, crow’s feet, forehead lines, frown lines (the “11s”), and perioral lines.
The multi-zone application and flip-design usage is demonstrated visually in the video, where Dr. Alexiades details the clinical rationale behind the mask’s engineering and its intended use beyond the traditional under-eye area.
These dermatologist-grade patches deliver MA37™, MACRENE actives’ patentmultitargeted active delivery technology, and are designed to work synergistically with the brand’s best-selling High Performance Eye Cream to visibly reduce the appearance of dark circles, puffiness, fine lines, and wrinkles, while restoring luminosity and skin resilience across the peri-ocular and adjacent facial regions.
Founded by Dr. Alexiades—world-renowned, Harvard-educated, double board-certified dermatologist and PhD genetic scientist—MACRENE actives continues to advance clean, clinically efficacious formulations alongside design-led innovations that expand how topical skincare functions. The High Performance Eye Mask delivers the patented MA37™ formulation via plant-based biocellulose, enabling rapid infusion of actives into the skin in under 30 minutes.
MACRENE actives’ proprietary MA37™ complex is engineered to deliver measurable skin benefits through a concentrated blend of peptides, DNA repair technology, dark-circle-reducing actives, hyaluronic acid, microbiome-rebalancing ingredients, caffeine, and plant-derived polyphenols, supporting visible smoothing, brightening, and rejuvenation.
“I always look to the latest research and clinical findings, and my goal with the High Performance Eye Mask was to engineer a plant-based alternative capable of addressing concerns traditionally treated with injectables or lasers,” says Dr. Macrene Alexiades, Founder and CEO of MACRENE actives. “By designing a dual-sided mask with active-saturated liners on both sides, we created a single treatment that functions beyond the under-eye—allowing precision care across multiple facial zones.”
Dr. Alexiades’ mission is to translate cosmetic procedures into plant-based actives that replace toxins in dermatologic care. Sustainability is integral to the product’s design: the High Performance Eye Mask is composed of plant-based biocellulose, packaged in uncoated paperboard cartons printed with vegetal biodegradable inks, and formulated with plant-sourced, certified organic, and eco-certified ingredients.
The MACRENE actives High Performance Eye Mask retails for $20 for a single pack and $115 for a six-pack