{"title":"Macrene Actives","description":"","products":[{"product_id":"high-performance-face-cream","title":"High Performance Face Cream","description":"\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Performance Face Cream\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eArchitectural support for the skin — built around ingredients almost nobody else in skincare will work with.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe High Performance Face Cream is not a moisturizer in the conventional sense. It is a structural treatment in cream form, anchored by the patented MA37® complex — Dr. Alexiades's proprietary system of 37 classes of actives that defines every formula in the collection — and elevated here by two of the most technically demanding and rarely used ingredients in modern dermatology: copper lysinate\/prolinate and a \u003cmeta charset=\"utf-8\"\u003ePlankton, Micrococcus, Arabidopsis DNA repair system\u003cb\u003e \u003c\/b\u003ethat sits at the frontier of skin science.\u003c\/p\u003e\n\u003cp\u003eWhere the High Performance Serum delivers intensive correction and lifting, this cream works beneath the surface to reinforce what holds skin together: barrier integrity, collagen architecture, elasticity, and sustained hydration.\u003c\/p\u003e\n\u003cp\u003eThink of it as the foundation your serum builds on.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMA37® patented complex\u003c\/strong\u003e — The scientific foundation of the entire DR. MACRENE actives line. MA37® refers to Dr. Alexiades's patented system of 37 classes of actives — the broadest multi-pathway approach to skin aging in the collection, addressing firmness, hydration, barrier integrity, environmental defense, cellular repair, and luminosity simultaneously. Every product in the line is built on this architecture. The cream deploys it in full.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCopper lysinate\/prolinate — a rarely used, technically demanding copper peptide\u003c\/strong\u003e — Not all copper peptides are equal. This is copper chelated to lysine and proline — the precise amino acid building blocks of collagen — making it exceptionally bioavailable, stable, and targeted in a way standard copper peptide forms are not. Once absorbed, it directly stimulates collagen and elastin synthesis and accelerates skin repair at the fibroblast level. It is one of the most clinically validated actives in dermatology — and one of the least used in skincare, because its stability requirements and cost make it difficult to formulate with correctly. Dr. Alexiades formulated with it anyway, because the clinical evidence left no other choice.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cb\u003ePlankton, Micrococcus, Arabidopsis DNA repair system — the ingredients almost no one works with\u003c\/b\u003e \u003c\/strong\u003e— Marine and terrestrial plant enzyme extracts with a scientifically  documented ability to repair UV-induced DNA damage in skin cells — the cumulative damage that, left unaddressed, drives accelerated aging, loss of firmness, and long-term structural breakdown. It is costly, pH-sensitive, reactive with common preservative systems, and technically demanding to keep stable in a finished formula. Very few formulators attempt it. Dr. Alexiades includes it because the mechanism is irreplaceable and her scientific background gives her the tools to do it right.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eErgothioneine\u003c\/strong\u003e — One of the most potent and stable antioxidants known to science, with a dedicated cellular transporter in human skin. Protects mitochondrial DNA from oxidative damage and has been associated with slowing the cellular aging process itself. Rarely seen in skincare due to its cost and sourcing complexity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrganic mushroom extract (Tremella fuciformis)\u003c\/strong\u003e — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration while supporting the skin's own moisture regulation mechanisms.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive-derived lipids \u0026amp; squalane\u003c\/strong\u003e — Structurally similar to the skin's own lipid barrier, these replenish the protective layer that locks moisture in and keeps environmental aggressors out, restoring suppleness without heaviness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAntioxidant complex\u003c\/strong\u003e — Edelweiss, microalgae, plankton, green coffee, yerba mate, feverfew, resveratrol, and stabilized vitamin C form a comprehensive defense against the oxidative stress that degrades collagen, accelerates fine lines, and diminishes radiance over time.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFull amino acid complex\u003c\/strong\u003e — Mirrors the skin's own natural moisturizing factors to continuously restore softness, barrier integrity, and the appearance of smooth, healthy skin.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eHow It Works With Your Routine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe High Performance Face Cream is the second step in Dr. Alexiades's two-product treatment system:\u003c\/p\u003e\n\u003cp\u003eSerum → intensive correction, lifting, and active delivery\u003c\/p\u003e\n\u003cp\u003eCream → barrier reinforcement, structural support, and moisture lock\u003c\/p\u003e\n\u003cp\u003eThe serum opens the pathway. The cream seals and rebuilds. Used together, they address skin aging at every level — from cellular repair to surface resilience.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eThe Science Behind the Formula\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMost luxury creams compete on texture and fragrance. Dr. Alexiades competed on mechanism. The MA37® complex is the product of her clinical and scientific research — a patented approach that targets the skin's own repair pathways rather than simply sitting on the surface. The copper lysinate\/prolinate and Micrococcus lysate at its core are not shortcuts — they are the hardest ingredients in this formula to source, stabilize, and deliver effectively. They are here because a physician with a PhD looked at the evidence and decided that difficulty was not a reason to leave them out.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Deeply hydrated, visibly smoother skin with a restored, supple feel.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Measurably firmer skin, softened fine lines and wrinkles, reduced redness, strengthened barrier function, and a sustained revitalized glow that reflects structurally healthier skin beneath the surface.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e","brand":"MACRENE actives","offers":[{"title":"1.0 oz.","offer_id":20820694663271,"sku":"501-INT","price":225.0,"currency_code":"USD","in_stock":true},{"title":"1.7 oz.","offer_id":20820694696039,"sku":"500-INT","price":345.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-face-cream-1.0oz-1.jpg?v=1729887202"},{"product_id":"high-performance-face-cream-extra-rich","title":"High Performance Face Cream Extra Rich","description":"\u003cp\u003e\u003cstrong\u003eThe same frontier-level actives as the High Performance Face Cream — in a richer, more deeply nourishing base built for dry skin, mature skin, compromised barriers, and the demands of winter or dry climates year-round.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis is an enriched version of the core formula — it is the same clinically rigorous active architecture, the same copper lysinate\/prolinate, the same Plankton, Micrococcus, Arabidopsis DNA repair system, the same MA37® patented complex of 37 active classes — delivered in a more emollient, barrier-intensive base designed for skin that needs more. Drier skin types. More mature skin. Skin compromised by climate, over-exfoliation, or a weakened barrier. And anyone whose skin has reached the stage of life where a standard cream is no longer enough.\u003c\/p\u003e\n\u003cp\u003eWhere the High Performance Face Cream is the architectural foundation, the Extra Rich is the same foundation reinforced — deeper nourishment, stronger barrier repair, and the sustained hydration that dry and mature skin demands year-round.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhat Makes It Richer\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe Extra Rich replaces the lighter squalane-forward base of the original cream with a more emollient system built on hydrogenated olive oil unsaponifiables, cocoa seed butter, hydrogenated coco-glycerides, and jojoba esters — a quartet of plant-derived lipids that are structurally closer to the skin's own barrier composition than conventional emollients, delivering richness that absorbs rather than sits.\u003c\/p\u003e\n\u003cp\u003eThe result is a noticeably more nourishing texture that melts into skin without heaviness, providing the sustained occlusion that compromised and dry skin barriers need to stop transepidermal water loss and begin genuinely rebuilding.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKey Actives\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMA37® patented complex\u003c\/b\u003e — Dr. Alexiades's patented system of 37 classes of actives, the scientific foundation of every DR. MACRENE actives formula. Deployed here in full, addressing firmness, hydration, barrier integrity, environmental defense, cellular repair, and luminosity simultaneously — in a base engineered to deliver them deeper into dry, barrier-compromised skin.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCopper lysinate\/prolinate — a rarely used, technically demanding copper peptide\u003c\/b\u003e — Copper chelated to lysine and proline, the amino acid building blocks of collagen, for exceptional bioavailability and stability. Directly stimulates collagen and elastin synthesis at the fibroblast level, accelerates skin repair, and visibly firms and restructures over time. One of the most clinically validated actives in dermatology — and one of the least used in skincare due to its formulation complexity and cost. Present here because dry and mature skin needs collagen support most.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003cmeta charset=\"utf-8\"\u003ePlankton, Micrococcus, Arabidopsis DNA repair system — the ingredients almost no one works with\u003c\/b\u003e — Marine and terrestrial plant enzyme extracts with a scientifically documented ability to repair UV-induced DNA damage in skin cells. Costly, pH-sensitive, reactive with common preservative systems, and technically demanding to stabilize. Very few formulators attempt it. The cumulative DNA damage it addresses is amplified in dry, mature, and barrier-compromised skin — making its inclusion here not just scientifically justified but clinically essential.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eErgothioneine\u003c\/b\u003e — A longevity molecule with a dedicated cellular transporter in human skin, protecting mitochondrial DNA from oxidative damage. Rarely seen in skincare due to cost and sourcing complexity. Particularly valuable for mature skin where cellular antioxidant defenses are diminished.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCocoa seed butter \u0026amp; jojoba esters\u003c\/b\u003e — Deep nourishing emollients that reinforce the lipid barrier and restore the skin's natural ability to retain moisture, providing the sustained occlusion that dry and compromised skin cannot generate on its own.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHydrogenated olive oil unsaponifiables\u003c\/b\u003e — The biologically active fraction of olive oil, rich in squalene precursors and phytosterols that mimic the skin's own lipid structure. Deeply regenerative for barrier-depleted skin, restoring elasticity and suppleness with a richness that does not feel heavy.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSilver ear mushroom extract (Tremella fuciformis)\u003c\/b\u003e — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration while supporting the skin's own moisture regulation — particularly important in dry climates and winter conditions where atmospheric humidity is low.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHydrolyzed hyaluronic acid\u003c\/b\u003e — Small-molecule HA for maximum penetration, drawing moisture into the deeper skin layers where dry and mature skin needs it most.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAntioxidant complex\u003c\/b\u003e — Edelweiss, microalgae, plankton, green coffee, yerba mate, feverfew, red algae, resveratrol, and stabilized vitamin C form a comprehensive defense against the environmental oxidative stress that is amplified in winter conditions and compromised skin.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFull amino acid complex\u003c\/b\u003e — Mirrors the skin's own natural moisturizing factors to continuously restore barrier integrity, softness, and the appearance of smooth, healthy skin — replenishing what dry and mature skin is no longer producing efficiently on its own.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCaffeine \u0026amp; bisabolol\u003c\/b\u003e — Targeted depuffing and botanical anti-inflammatory support to calm the redness and chronic low-grade inflammation that compromised barrier skin is particularly prone to.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWho It Is For\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThis cream is for you if your skin feels tight after cleansing, drinks in moisturizer without feeling satisfied, reacts to cold air or dry environments, or has simply reached the stage of life where a standard cream is no longer enough. It is also the right choice for anyone whose barrier has been compromised by over-exfoliation, retinoids, or aggressive treatments.\u003c\/p\u003e\n\u003cp\u003eUse it as your winter cream, your dry-climate travel companion, or your year-round solution if your skin has always leaned dry.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHow It Works With Your Routine\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eSerum → intensive correction, lifting, and active delivery\u003c\/p\u003e\n\u003cp\u003eExtra Rich Cream → deep barrier reinforcement, structural rebuilding, and sustained moisture lock\u003c\/p\u003e\n\u003cp\u003eThe serum opens the pathway. The Extra Rich Cream seals, nourishes, and rebuilds at the level dry and mature skin actually requires.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Science Behind the Formula\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe same ingredients that make the High Performance Face Cream exceptional — the copper lysinate\/prolinate, the Micrococcus lysate, the ergothioneine — are present here in a base that was specifically engineered to deliver them to skin that has lost its ability to hold onto moisture and maintain its own barrier. Dr. Alexiades did not simply add more emollient to the original formula. She rebuilt the base around the biology of dry and compromised skin — then loaded it with the same frontier-level actives that make the original cream unlike anything else on the market.\u003c\/p\u003e\n\u003cp\u003eThe difficulty of sourcing and stabilizing these ingredients does not change between formulas. What changes is who needs them most. And dry, mature, barrier-compromised skin needs them most.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhat You Will See\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Deeply nourished, visibly smoother skin with an immediate sense of relief, restored suppleness, and a rich but non-greasy feel.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Measurably firmer skin, softened fine lines and wrinkles, significantly reduced dryness and tightness, strengthened barrier function, reduced redness, and a sustained healthy glow that reflects skin that is genuinely more resilient — through winter and beyond.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"1.0 oz.","offer_id":20820720746599,"sku":"503-INT","price":265.0,"currency_code":"USD","in_stock":true},{"title":"1.7 oz.","offer_id":20820720779367,"sku":"502-INT","price":385.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-face-cream-extra-rich-1.0oz-1.jpg?v=1729887487"},{"product_id":"high-performance-cleansing-treatment","title":"High Performance Cleanser","description":"\u003cp\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003eDR. MACRENE \u003cem\u003eactives\u003c\/em\u003e High Performance Cleanser is specially formulated to maintain proper pH and balance. This cleanser formula uses plant surfactants to gently exfoliate while it hydrates, balances, clarifies and helps reduce the appearance of fine lines and wrinkles. \u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eRich with organic anti-aging antioxidants including green tea, aloe, olive leaf and mint extracts, it l\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eathers into a foam\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e that cleans and treats skin while helping reduce the appearance of blemishes. Gentle enough for sensitive, irritable skin.\u003c\/span\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Luxe \/ 3.4 oz.","offer_id":20820728938599,"sku":"504-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ 1.0 oz.","offer_id":40914058576065,"sku":"516-INT","price":45.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ 2.0 oz.","offer_id":45232197173489,"sku":"410","price":85.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ 1.0 oz.","offer_id":45232197206257,"sku":"409","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/Eco_2.0_oz..jpg?v=1737638914"},{"product_id":"high-performance-neck-and-decolletage-treatment","title":"High Performance Neck and Décolletage Treatment","description":"\u003cp\u003e\u003cstrong\u003eHigh Performance Neck \u0026amp; Décolletage Treatment\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe neck and décolletage age faster than the face — and are almost always treated as an afterthought. This formula was built to correct that.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe skin of the neck and décolletage is thinner, has fewer sebaceous glands, is subjected to constant movement, and receives decades of sun exposure with a fraction of the skincare attention given to the face. The result is crepiness, loss of elasticity, brown spots, and a texture that no amount of facial treatment can address. Dr. Alexiades formulated this treatment specifically for that biology — a potent, peptide-rich active system targeting the precise mechanisms of neck and décolletage aging: elasticity loss, sun damage, uneven tone, and the fine lines and wrinkles that develop uniquely in this area.\u003c\/p\u003e\n\u003cp\u003eFirm. Plump. Even. Revive.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDipalmitoyl hydroxyproline — the elasticity peptide\u003c\/strong\u003e — A targeted peptide specifically validated for its ability to stimulate elastin synthesis and restore the elastic fiber network that gives neck skin its suppleness and recoil. Elasticity loss is the primary driver of crepiness and sagging in the neck and décolletage — this is the active that addresses it directly at the structural level.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStabilized vitamin C (tetrahexyldecyl ascorbate) \u0026amp; resveratrol — sun damage reversal\u003c\/strong\u003e — An oil-soluble, stabilized vitamin C that penetrates where conventional vitamin C cannot, working synergistically with resveratrol to visibly brighten brown spots, even skin tone, and reverse the oxidative damage accumulated from years of UV exposure on the décolletage. The combination addresses both existing pigmentation and the inflammatory pathways that drive new spot formation.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisodium acetyl glucosamine phosphate\u003c\/strong\u003e — A targeted brightening and exfoliating active that works at the surface to reduce the appearance of uneven pigmentation, refine skin texture, and improve the clarity and luminosity of sun-damaged skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCitrulline \u0026amp; citrullus lanatus (watermelon) extract\u003c\/strong\u003e — A clinically relevant pairing for skin barrier function and hydration. Citrulline is an amino acid precursor to arginine that supports the skin's own nitric oxide production, improving microcirculation and the delivery of actives to the treatment area. Watermelon extract amplifies the hydration and plumping effect for a visibly more supple, revived texture.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKappaphycus alvarezii (red marine algae) extract\u003c\/strong\u003e — A clinically studied marine active with documented ability to firm and tone skin by supporting the extracellular matrix — the structural scaffolding that gives skin its density and resistance to crepiness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSilver ear mushroom extract (Tremella fuciformis)\u003c\/strong\u003e — A botanical hyaluronic acid alternative with superior water-holding capacity, delivering deep sustained hydration and visible plumping to the thin, dehydration-prone skin of the neck area.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHydrolyzed hyaluronic acid\u003c\/strong\u003e — Small-molecule HA for maximum penetration, drawing moisture into the deeper layers of neck and décolletage skin where hydration is most needed and most rapidly lost.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEight-plant antioxidant shield\u003c\/strong\u003e — Green tea, pomegranate, feverfew, yerba mate, green coffee, cocoa seed butter, edelweiss, microalgae, rosemary, sunflower, and rice bran form a comprehensive defense against the UV-induced and environmental oxidative stress that is the primary driver of brown spots, uneven tone, and accelerated aging in the décolletage.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCaffeine\u003c\/strong\u003e — Targets sluggish microcirculation in the neck area, reducing puffiness and the dull, congested appearance that compromised circulation creates in thinner skin.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFull amino acid complex\u003c\/strong\u003e — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring the barrier integrity and softness that neck and décolletage skin loses with age and sun exposure.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOlive-derived lipids, jojoba esters \u0026amp; squalane\u003c\/strong\u003e — A trio of structurally skin-identical emollients that replenish the lipid barrier, restore suppleness, and deliver the nourishing richness that the relatively sebaceous-gland-poor skin of the neck and décolletage cannot produce on its own.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhat It Addresses\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eCrepiness \u0026amp; elasticity loss → dipalmitoyl hydroxyproline and red marine algae rebuild the elastic fiber network and extracellular matrix\u003c\/p\u003e\n\u003cp\u003eBrown spots \u0026amp; sun damage → stabilized vitamin C, resveratrol, and disodium acetyl glucosamine phosphate brighten and reverse pigmentation\u003c\/p\u003e\n\u003cp\u003eFine lines \u0026amp; wrinkles → peptide system, multi-weight hyaluronic acid, and amino acid complex plump and smooth from within\u003c\/p\u003e\n\u003cp\u003eDullness \u0026amp; uneven tone → eight-plant antioxidant shield and brightening complex restore clarity and radiance\u003c\/p\u003e\n\u003cp\u003eDryness \u0026amp; crepey texture → olive-derived lipids, silver ear mushroom, and squalane nourish and restore suppleness\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eThe Science Behind the Formula\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe neck and décolletage present a clinical challenge that most skincare brands simply repurpose face cream to address. Dr. Alexiades did not. This formula was built around the specific biology of neck skin — its thinner structure, its elasticity dependence, its history of cumulative UV damage, and its unique need for both barrier repair and active treatment simultaneously. Dipalmitoyl hydroxyproline is the kind of targeted, mechanism-specific active that only appears in a formula when the formulator understood exactly what problem they were solving for.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eHow To Use\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eApply to neck and décolletage morning and evening after serum, using upward strokes from the chest to the jawline. For the décolletage, smooth outward from the sternum. Use consistently — the elasticity and pigmentation changes this formula targets are built over time, and the results compound with continued use.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Visibly more hydrated, smoother, and more supple neck and décolletage skin with a nourished, revived feel.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Measurably improved elasticity and firmness, visibly reduced crepiness, brightened brown spots, more even skin tone, softened fine lines and wrinkles, and a sustained luminosity that reflects skin that has been genuinely treated — not just moisturized.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"3.4 oz.","offer_id":30005849522279,"sku":"505-INT","price":315.0,"currency_code":"USD","in_stock":true},{"title":"1.0 oz.","offer_id":40914069291201,"sku":"517-INT","price":125.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-neck-deck-3.4oz-1.jpg?v=1729887839"},{"product_id":"high-performance-face-serum","title":"High Performance Face Serum","description":"\u003cp\u003e\u003cstrong\u003eHigh Performance Face Serum\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe most advanced serum in the collection — 50 actives, one patented complex, every pathway of visible skin aging addressed.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThis is the product Dr. Alexiades built in her quest to stave off plastic surgery. Not a single-ingredient serum with a compelling story — a comprehensive, 50-active treatment formula anchored by the patented MA37® peptide DNA repair complex, designed to address loss of firmness, uneven tone, dehydration, and environmental damage simultaneously and at the level of clinical precision.\u003c\/p\u003e\n\u003cp\u003eWhere most serums pick one mechanism and optimize for it, this one was formulated the way a dermatologist thinks: every pathway matters, every active earns its place, and the delivery system is engineered to make sure it all actually reaches the skin.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMA37® patented peptide DNA repair complex\u003c\/strong\u003e — Dr. Alexiades's proprietary innovation, available exclusively in DR. MACRENE actives formulas. Developed from her research background in cellular biology, this complex targets the skin's own DNA repair mechanisms to visibly firm, lift, and restore at a level no standard peptide ingredient can achieve. This is the scientific core of the entire collection.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdvanced firming and lifting peptide system\u003c\/strong\u003e — A multi-peptide architecture clinically shown to visibly firm and lift skin over time, signaling collagen and elastin synthesis and reinforcing the structural proteins that give skin its density and resilience.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicro-encapsulated hyaluronic acids\u003c\/strong\u003e — Encapsulation technology controls the rate of delivery and ensures hyaluronic acid reaches deeper skin layers rather than evaporating at the surface — maximizing sustained hydration, plumping fine lines from within, and maintaining skin comfort throughout wear.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDNA-supporting enzymes\u003c\/strong\u003e — Work in concert with the MA37® complex to support the skin's natural repair mechanisms, addressing the cellular-level damage that accumulates from UV exposure, pollution, and biological aging.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePotent antioxidant complex\u003c\/strong\u003e — A broad-spectrum environmental defense system targeting free radical damage, oxidative stress, and the inflammatory pathways that drive premature aging, loss of radiance, and uneven tone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRedness-reducing and brightening actives\u003c\/strong\u003e — Targeted ingredients that calm visible redness and unevenness while improving clarity, tone, and the overall luminosity of the skin surface.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eThe Delivery System\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFifty actives are only as effective as their ability to reach the skin. Dr. Alexiades built microencapsulation technology into the core of this formula to ensure controlled, sustained release — ingredients delivered at the right depth, at the right rate, without overwhelming the skin's barrier. The result is maximum efficacy without irritation, even for sensitive skin types.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eHow It Works With Your Routine\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe High Performance Face Serum is the first step in Dr. Alexiades's two-product treatment system:\u003c\/p\u003e\n\u003cp\u003eSerum → intensive correction, lifting, active delivery, and multi-pathway treatment\u003c\/p\u003e\n\u003cp\u003eCream → barrier reinforcement, structural support, and moisture lock\u003c\/p\u003e\n\u003cp\u003eThe serum opens the pathway. The cream seals and rebuilds. Used together, they address skin aging at every level — from cellular DNA repair to surface resilience.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eThe Science Behind the Formula\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eFifty actives is not a marketing number — it is the result of a physician asking what it would take to address every visible dimension of skin aging in a single formula. Firmness, tone, hydration, environmental defense, redness, radiance — each requires a different mechanism, a different class of ingredient, and a different delivery strategy. Dr. Alexiades designed this serum the way she designs a clinical treatment protocol: comprehensively, precisely, and without compromise.\u003c\/p\u003e\n\u003cp\u003eThe MA37® complex is the anchor. Everything else is the supporting system that makes it perform.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Visibly smoother, more hydrated, and more luminous skin with a lifted, refined appearance.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Measurably firmer skin, improved tone and texture, reduced redness and unevenness, and a sustained clarity and resilience that reflects genuinely healthier skin at the cellular level.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Luxe \/ 1.0 oz.","offer_id":45232161226993,"sku":"510-INT","price":195.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ 1.0 oz.","offer_id":45232161259761,"sku":"406","price":195.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ 0.5 oz.","offer_id":45232161292529,"sku":"405","price":115.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-serum-regular-1.jpg?v=1729888016"},{"product_id":"high-performance-tinted-moisturizer","title":"High Performance Tinted Moisturizer","description":"\u003cdiv class=\"flex-1 flex flex-col px-4 max-w-3xl mx-auto w-full pt-1\"\u003e\n\u003cdiv class=\"[content-visibility:auto] [contain-intrinsic-size:auto_400px] pb-8 -mb-8 print:[content-visibility:visible]\"\u003e\n\u003cdiv data-test-render-count=\"1\"\u003e\n\u003cdiv class=\"group\"\u003e\n\u003cdiv class=\"contents\"\u003e\n\u003cdiv data-is-streaming=\"false\" class=\"group relative relative pb-3\"\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eHigh Performance Tinted Moisturizer\u003c\/b\u003e \u003ci\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/i\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eYour skin, perfected — a sheer, color-adapting veil of hydration, brightening, and environmental defense.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eWhere the High Performance Concealer builds coverage, the Tinted Moisturizer does something more nuanced: it evens, brightens, and protects while letting your skin show through. Formulated on the same clinical active base Dr. Alexiades developed for the concealer — the same four forms of hyaluronic acid, the same eight-plant antioxidant shield, the same full amino acid complex — but worn as a daily treatment moisturizer that carries a sheer, luminous wash of adaptive color.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eThis is not a tinted moisturizer that happens to have some actives. It is a dermatologist's treatment formula that happens to give you a beautiful finish.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eAvailable in six color-adapting shades.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eKey Actives\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eBrightening complex — resveratrol \u0026amp; tetrahexyldecyl ascorbate (stabilized vitamin C)\u003c\/b\u003e — A stabilized, oil-soluble vitamin C paired with resveratrol penetrates where conventional vitamin C cannot, visibly evening skin tone, reducing the appearance of dark spots, and imparting lasting luminosity beneath the adaptive tint.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eMilk thistle (Silybum marianum ethyl ester)\u003c\/b\u003e — A rare, clinically-relevant botanical antioxidant and anti-inflammatory that calms reactive skin while protecting against the oxidative damage that drives uneven tone and dullness.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eEight-plant anti-pollutant shield\u003c\/b\u003e — Epigallocatechin gallate and its glucoside derivative, green tea leaf extract, ginkgo biloba, pomegranate, feverfew, yerba mate, and coffee seed extract form a comprehensive defense against environmental aggressors — particulate pollution, UV-induced oxidative stress, and infrared damage — that are the primary drivers of premature skin aging and loss of radiance.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eSuperoxide dismutase\u003c\/b\u003e — One of the skin's own endogenous antioxidant enzymes, included at a clinical level to neutralize free radical damage at the cellular level before it translates to visible aging.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eFour forms of hyaluronic acid\u003c\/b\u003e — Sodium hyaluronate, sodium acetylated hyaluronate, sodium hyaluronate crosspolymer, and hydrolyzed sodium hyaluronate work at different molecular weights and depths for layered, all-day hydration that plumps fine lines from within.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eFull amino acid complex\u003c\/b\u003e — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring softness, barrier integrity, and the appearance of smooth, healthy skin.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eBisabolol \u0026amp; tocopherol\u003c\/b\u003e — Botanical soothing and vitamin E antioxidant support to calm inflammation and protect the skin's lipid barrier throughout the day.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eThe Finish\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eSheer, luminous, and skin-like. Six color-adapting shades flex to meet your skin tone rather than sitting on top of it, delivering the look of well-rested, evenly-lit skin with no visible product line.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eWear alone for a light, natural finish or layer under the High Performance Concealer for targeted coverage where needed.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eShade guide:\u003c\/b\u003e Light or Light-Medium → porcelain skin tones Medium or Medium-Deep → fair to light tan skin tones Deep or Extra Deep → tan to dark skin tones\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eThe Science Behind the Glow\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003ePollution, UV exposure, and oxidative stress are the three primary environmental drivers of dullness, uneven tone, and accelerated fine lines. Dr. Alexiades built the anti-pollutant and brightening architecture of this formula around the same multi-pathway defense strategy she applies clinically — not a single hero ingredient, but a layered system of antioxidants working at different mechanisms simultaneously. The result is a daily wear product that actively counters the damage your skin accumulates every day you put it on.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003eWhat You Will See\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eImmediately: A sheer, luminous, color-adapted finish that evens skin tone and imparts a natural, healthy glow.\u003c\/p\u003e\n\u003cp class=\"p1\"\u003eWith regular use: Visibly reduced fine lines and wrinkles, improved radiance, more even skin tone, and measurably better defense against the daily environmental stressors that age skin prematurely.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv data-test-render-count=\"1\"\u003e\n\u003cdiv class=\"group\"\u003e\n\u003cdiv class=\"contents\"\u003e\n\u003cdiv data-is-streaming=\"false\" class=\"group relative relative pb-3\"\u003e\n\u003cdiv class=\"font-claude-response relative leading-[1.65rem] [\u0026amp;_pre\u0026gt;div]:bg-bg-000\/50 [\u0026amp;_pre\u0026gt;div]:border-0.5 [\u0026amp;_pre\u0026gt;div]:border-border-400 [\u0026amp;_.ignore-pre-bg\u0026gt;div]:bg-transparent [\u0026amp;_.standard-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [\u0026amp;_.standard-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8 [\u0026amp;_.progressive-markdown_:is(p,blockquote,h1,h2,h3,h4,h5,h6)]:pl-2 [\u0026amp;_.progressive-markdown_:is(p,blockquote,ul,ol,h1,h2,h3,h4,h5,h6)]:pr-8\" style=\"box-sizing: border-box; --tw-border-spacing-x: 0; --tw-border-spacing-y: 0; --tw-translate-x: 0; --tw-translate-y: 0; --tw-rotate: 0; --tw-skew-x: 0; --tw-skew-y: 0; --tw-scale-x: 1; --tw-scale-y: 1; --tw-scroll-snap-strictness: proximity; --tw-ring-offset-width: 0px; --tw-ring-offset-color: #fff; --tw-ring-color: hsl(var(--accent-100) \/ 1); --tw-ring-offset-shadow: 0 0 #0000; --tw-ring-shadow: 0 0 #0000; --tw-shadow: 0 0 #0000; --tw-shadow-colored: 0 0 #0000; outline-color: hsl(var(--accent-100)); position: relative; line-height: 1.65rem; font-family: var(--font-claude-response); border: 0px solid hsl(var(--border-100));\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003ca href=\"https:\/\/macreneactives.com\/pages\/how-to-know-which-tinted-moisturizer-and-concealer-shade-you-should-get\" title=\"Shade Selection Guide\" rel=\"noopener\" target=\"_blank\"\u003eShade Selection Guide\u003c\/a\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Luxe \/ Light \/ 1.0 oz.","offer_id":20820768096359,"sku":"506-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ Light-Medium \/ 1.0 oz.","offer_id":20820768129127,"sku":"520-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ Medium \/ 1.0 oz.","offer_id":42161871159537,"sku":"507-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ Medium-Deep \/ 1.0 oz.","offer_id":20820768161895,"sku":"521-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ Deep \/ 1.0 oz.","offer_id":42161867784433,"sku":"508-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Luxe \/ Extra Deep \/ 1.0 oz.","offer_id":42146065023217,"sku":"522-INT","price":175.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ Light \/ 0.5 oz.","offer_id":45231739568369,"sku":"417","price":85.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ Light-Medium \/ 0.5 oz.","offer_id":45231739601137,"sku":"420","price":85.0,"currency_code":"USD","in_stock":false},{"title":"Eco \/ Medium \/ 0.5 oz.","offer_id":45231739633905,"sku":"418","price":85.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ Medium-Deep \/ 0.5 oz.","offer_id":45231739666673,"sku":"421","price":85.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ Deep \/ 0.5 oz.","offer_id":45231739699441,"sku":"419","price":85.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ Extra Deep \/ 0.5 oz.","offer_id":45231739732209,"sku":"422","price":85.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-tm-regular-light-1.jpg?v=1729851029"},{"product_id":"high-performance-lip-filler","title":"High Performance Lip Filler","description":"\u003cp\u003e\u003cstrong\u003eHigh Performance Lip Filler\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe original. The only MD PhD-formulated lip filler clinically designed to replace the needle — not just plump the surface.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eDr. Alexiades spent decades injecting lips. She knows better than anyone what injectable filler does, how it does it, and what it cannot do. This formula was built from that clinical knowledge — not inspired by it, not approximating it, but engineered from the inside out to replicate the volumizing, smoothing, and structural mechanisms of injectable lip filler through a 20+ active system that works deeper, lasts longer, and improves with every application.\u003c\/p\u003e\n\u003cp\u003eWear it daily. The results compound over time. This is the lip treatment you use for decades so you do not need injections.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDipalmitoyl hydroxyproline — the structural plumping peptide\u003c\/strong\u003e — The same elastin-stimulating peptide Dr. Alexiades deploys in the Neck \u0026amp; Décolletage Treatment, here targeted to the lip's unique structural challenge: loss of the elastic fiber network that gives young lips their natural plushness, definition, and recoil. With consistent use, it signals the lip tissue to rebuild what time has taken — genuine structural improvement, not surface coating.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicro-encapsulated sodium hyaluronate — needle-free delivery\u003c\/strong\u003e — Conventional hyaluronic acid sits on the surface. Micro-encapsulation controls the rate of penetration and drives HA deeper into the lip tissue, replicating the volumizing mechanism of injectable HA filler without the needle. Hydration drawn in from within, not layered on top — the difference is visible and it compounds with use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCeramide NG — barrier and moisture lock\u003c\/strong\u003e — Ceramides are the lipid molecules that hold the lip's moisture barrier together. As lips age they lose ceramide content, leading to chronic dryness, feathering, and the loss of the soft, pillowy texture that characterizes healthy lips. Ceramide NG replenishes that barrier directly, locking moisture in and keeping environmental stressors out.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eEchium plantagineum seed oil — the rare omega powerhouse\u003c\/strong\u003e — One of the most remarkable and rarely used oils in skincare. Echium is exceptionally rich in stearidonic acid, gamma-linolenic acid, and alpha-linolenic acid — a unique fatty acid profile that makes it one of the most anti-inflammatory and barrier-restorative plant oils available. It is difficult to source, oxidation-sensitive, and rarely seen in lip formulas. It is here because no other plant oil delivers its combination of barrier repair, anti-inflammatory potency, and deep nourishment to the thin, vulnerable skin of the lip.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCamellia japonica seed oil — the skin-identical luxury oil\u003c\/strong\u003e — Cold-pressed from the Japanese camellia flower, this oil has a fatty acid composition remarkably similar to human sebum, allowing it to absorb instantly and completely without residue. Rich in oleic acid and squalene precursors, it restores suppleness, improves lip elasticity, and delivers a silky, non-sticky feel that distinguishes this formula from conventional lip treatments.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSolidago virgaurea (goldenrod) extract\u003c\/strong\u003e — A clinically relevant anti-inflammatory and antioxidant botanical that calms the chronic low-grade irritation that accelerates lip aging, reduces feathering, and contributes to the loss of lip definition over time. Rarely used in lip formulas — present here because inflammation is an underappreciated driver of lip volume loss.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCnidium monnieri fruit extract\u003c\/strong\u003e — A traditional botanical with documented skin-conditioning and barrier-strengthening properties, contributing to the sustained plumpness and silkiness of the lip surface with continued use.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eShea butter \u0026amp; shea butter unsaponifiables\u003c\/strong\u003e — Both the full butter and its biologically active unsaponifiable fraction are included — the butter for immediate nourishment and occlusion, the unsaponifiables for their unique ability to improve skin elasticity and barrier function at a deeper structural level than the butter alone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCoconut oil, squalane \u0026amp; sunflower oil unsaponifiables\u003c\/strong\u003e — A trio of skin-identical and skin-compatible lipids that deliver immediate softness, sustained hydration, and the lightweight, non-sticky base that makes this formula comfortable enough to wear daily and throughout the day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMentha arvensis oil\u003c\/strong\u003e — A gentle, natural mint oil that delivers an immediate sensation of freshness and stimulates microcirculation in the lip, enhancing the delivery of actives and contributing to the visible plumping effect from the first application. No need to carry mints when you have this balm in your purse or pocket.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTocopherol \u0026amp; rosemary leaf extract\u003c\/strong\u003e — Vitamin E and rosemary antioxidants protect the formula's rare and oxidation-sensitive plant oils from degradation, and help protect the lip tissue itself from the UV-induced and environmental oxidative stress that accelerates lip aging and pigmentation changes.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhy the Oils in This Formula Are Different\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMost lip treatments are built on mineral oil, petrolatum, or commodity plant oils. The High Performance Lip Filler was built on a curated system of rare, clinically selected oils chosen for their specific mechanisms — not their cost or availability. Echium for its unmatched fatty acid profile. Camellia japonica for its skin-identical composition. Shea unsaponifiables for barrier repair beyond what the butter alone can achieve. Soybean oil for its phytosterol content. Every oil in this formula earns its place against a specific mechanism of lip aging. There is no filler in a lip filler formulated by a physician.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Visibly softer, more hydrated, and more defined lips with a natural plumping sensation and a smooth, comfortable finish.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Gradually but consistently improved lip volume and definition, visibly reduced lip fine lines and feathering, restored moisture barrier, and the kind of sustained structural plushness that injectable filler provides — built over time, without the needle.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cblockquote\u003e\u003c\/blockquote\u003e","brand":"MACRENE actives","offers":[{"title":"Luxe \/ 0.27 oz.","offer_id":45232127639793,"sku":"509-INT","price":135.0,"currency_code":"USD","in_stock":true},{"title":"Eco \/ 0.2 oz.","offer_id":45232127672561,"sku":"401","price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-lip-filler-regular-1.jpg?v=1729887634"},{"product_id":"high-performance-concealer","title":"High Performance Concealer","description":"\u003cp\u003e\u003cb\u003eHigh Performance Concealer\u003c\/b\u003e \u003ci\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eA concealer that covers and treats simultaneously — formulated to the standard of a dermatologist's prescription.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eMost concealers mask. This one works. Lightweight with buildable coverage, the High Performance Concealer is loaded with the same caliber of actives Dr. Alexiades deploys clinically — while luxurious light-reflecting pigments adapt to your own skin tone for a finish that looks like skin, not makeup.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKey Actives\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMilk thistle (Silybum marianum ethyl ester)\u003c\/b\u003e — A rare, potent botanical antioxidant and anti-inflammatory. Soothes reactive and sensitized skin while protecting against oxidative stress and environmental damage.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFour forms of hyaluronic acid\u003c\/b\u003e — Sodium hyaluronate, sodium acetylated hyaluronate, sodium hyaluronate crosspolymer, and hydrolyzed sodium hyaluronate work at different molecular weights and depths to deliver layered, sustained hydration throughout the day.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSuperoxide dismutase\u003c\/b\u003e — One of the skin's own endogenous antioxidant enzymes, included here at a clinical level to neutralize free radical damage at the cellular level.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eEight plant antioxidants\u003c\/b\u003e — Epigallocatechin gallate and its glucoside derivative, green tea leaf extract, ginkgo biloba, pomegranate, feverfew, yerba mate, and coffee seed extract form a comprehensive environmental defense shield.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eResveratrol \u0026amp; tetrahexyldecyl ascorbate\u003c\/b\u003e — A stabilized, oil-soluble form of vitamin C paired with resveratrol for brightening, anti-aging, and antioxidant synergy that penetrates where water-soluble vitamin C cannot.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFull amino acid complex\u003c\/b\u003e — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors to restore softness and barrier integrity over time.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBisabolol \u0026amp; tocopherol\u003c\/b\u003e — Botanical-derived soothing and vitamin E antioxidant support, calming inflammation while protecting lipid integrity in the skin barrier.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Coverage\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eLightweight and blendable, with coverage that builds from sheer to full without caking or settling into fine lines. Luxurious pigments reflect and adapt to your skin tone for a natural finish that moves with skin rather than sitting on top of it. Use for targeted spot treatment or broader coverage — the formula performs at every application level.\u003c\/p\u003e\n\u003cp\u003eAvailable in six shades.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eShade guide:\u003c\/b\u003e Light or Light-Medium → porcelain skin tones Medium or Medium-Deep → fair to light tan skin tones Deep or Extra Deep → tan to dark skin tones\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Science Behind the Shade\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eConventional concealers are built around pigment and filler. This formula was built around an active treatment base first — then perfected for coverage. The result is a product that does what no standard concealer can: smooth, hydrate, soothe, and defend the skin it sits on, every time it is worn.\u003c\/p\u003e\n\u003cp\u003eNote for next packaging update: Silybum marianum ethyl ester to be labeled as Milk Thistle on front of pack.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhat You Will See\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Seamless, natural-finish coverage that adapts to your skin tone and does not settle into fine lines.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Smoother skin texture, improved hydration, reduced redness and reactivity, and a more even complexion beneath and beyond where the concealer is applied.\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Light","offer_id":32087654563943,"sku":"512-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Light-Medium","offer_id":42738567414001,"sku":"523-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Medium","offer_id":32087654596711,"sku":"513-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Medium-Deep","offer_id":42738570690801,"sku":"524-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Deep","offer_id":32087654629479,"sku":"514-INT","price":95.0,"currency_code":"USD","in_stock":true},{"title":"Extra Deep","offer_id":42738574328049,"sku":"525-INT","price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-concealer-light-1.jpg?v=1744822140"},{"product_id":"high-performance-neck-and-decolletage-treatment-sachet","title":"High Performance Neck and Décolletage Treatment Sachet","description":"","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":32825133105255,"sku":"616","price":0.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/3_MacreneActives_HP_FaceCream_50ml_Primary_1.png?v=1700066937"},{"product_id":"luxury-mini-high-performance-cleanser-30ml","title":"Luxury Mini: High Performance Cleanser","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan\u003eSpecially formulated to maintain proper pH and microbiome, this cleanser will firm, tone, and smooth skin texture, while regulating sebum production and helping to reduce the appearance of fine lines and wrinkles. \u003c\/span\u003e\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eRich with organic anti-aging antioxidants including green tea, aloe, olive leaf and mint extracts, it l\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003eathers into a foam\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e that cleans and treats skin while decreasing the appearance of blemishes, redness, and sun damage. Gentle enough for sensitive, irritable skin.\u003c\/span\u003e\u003c\/p\u003e","brand":"Macrene Actives","offers":[{"title":"Default Title","offer_id":32930819735655,"sku":"516-INT","price":45.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/MA_Product-Essentials-Mini-Cleanser-3934_1_f9e1772b-aac3-4912-ae69-6d9c16e7255c.jpg?v=1705945317"},{"product_id":"macrene-actives-organic-hemp-zip-pouch","title":"Organic Hemp \u0026 Organic Cotton Lined Large Zip Pouch","description":"\u003cp\u003eDesigned by Dr. Macrene, this large, deluxe organic hemp and organic cotton lined zip pouch is beautiful, sustainable, and washable. Use it to travel with your favorite DR. MACRENE \u003cem\u003eactives\u003c\/em\u003e products, where Science Meets Nature. \u003c\/p\u003e\n\u003cp\u003eMeasurements: 13 x 8 inches (33 x 20 cm)\u003c\/p\u003e","brand":"Macrene Actives","offers":[{"title":"Default Title","offer_id":37749750923457,"sku":"376","price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-hemp-bag-1.jpg?v=1741945821"},{"product_id":"high-performance-eye-cream","title":"High Performance Eye Cream","description":"\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cb\u003eHigh Performance Eye Cream\u003c\/b\u003e \u003ci\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eA complete clinical treatment for the most revealing area of the face — 38 plant actives, peptides, and hyaluronic acid in one clean, vegan, fragrance-free formula.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eThe eye area ages differently than the rest of the face — thinner skin, constant movement, and a unique circulatory vulnerability that drives dark circles and puffiness. Dr. Alexiades formulated this cream specifically for that biology, building a 38-active system around the precise mechanisms that make the eye area so difficult to treat. Scientifically proven and dermatologist-tested to illuminate, depuff, and visibly reduce the appearance of fine lines and wrinkles.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKey Actives\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePalmitoyl hexapeptide-12\u003c\/b\u003e — A targeted firming peptide clinically validated for the eye area, signaling collagen and elastin synthesis to visibly lift, firm, and smooth the delicate skin around the eye with consistent use.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCaffeine\u003c\/b\u003e — The most clinically supported active for under-eye circles and puffiness. Caffeine constricts blood vessels, reducing the pooling of hemoglobin pigment that causes dark circles, while its anti-inflammatory properties visibly reduce morning puffiness and fluid retention.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHydrolyzed hyaluronic acid\u003c\/b\u003e — Broken down to its smallest molecular weight for maximum penetration into the thin skin of the eye area, delivering deep, sustained hydration that plumps fine lines and restores suppleness where the skin is most vulnerable to dehydration.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eFull amino acid complex\u003c\/b\u003e — Arginine, glycine, alanine, serine, valine, proline, threonine, isoleucine, histidine, and phenylalanine mirror the skin's own natural moisturizing factors, continuously restoring the barrier integrity and softness that the eye area loses first with age.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCocoa seed butter, jojoba esters \u0026amp; hydrogenated olive oil\u003c\/b\u003e — A trio of plant-derived emollients and lipids that deeply nourish and reinforce the skin barrier without heaviness, restoring the suppleness and elasticity that thin eye area skin requires.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSqualane\u003c\/b\u003e — A lightweight, skin-identical lipid that absorbs instantly and locks moisture in without occlusion, making it ideal for the eye area where heavier emollients can cause milia.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eEight-plant antioxidant shield — rosemary, coffee seed, yerba mate, sunflower, rice bran\u003c\/b\u003e — A comprehensive botanical antioxidant system targeting the oxidative stress and chronic low-grade inflammation that drive accelerated aging, pigmentation, and loss of resilience specifically in the periorbital area.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBisabolol \u0026amp; tocopherol\u003c\/b\u003e — Botanical soothing and vitamin E antioxidant support to calm the chronic inflammation that contributes to both dark circles and visible aging around the eye.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGluconolactone \u0026amp; calcium gluconate\u003c\/b\u003e — A polyhydroxy acid pairing that gently resurfaces and brightens the eye area without the irritation risk of AHAs, improving skin texture, tone, and radiance while strengthening barrier function.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSodium PCA \u0026amp; sodium lactate\u003c\/b\u003e — Skin-identical humectants from the natural moisturizing factor that bind water within the skin layers, sustaining hydration long after application.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eThe Formulation Standard\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eClean. Vegan. Fragrance-free. Every ingredient chosen with the knowledge that the eye area is the most sensitive skin on the face — and the most unforgiving of irritation. There are no shortcuts in this formula and no filler ingredients. Every one of the 38 plant actives earns its place against a specific mechanism of eye area aging.\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eWhat You Will See\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Visibly brighter, more awake eyes with reduced puffiness and a smoother, more hydrated appearance around the eye contour.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Measurably reduced dark circles, visibly softened fine lines and crow's feet, firmer and more elastic skin around the eye area, and a sustained luminosity that reflects genuinely healthier periorbital skin over time.\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":43167288426737,"sku":"519-INT","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-eye-cream-1.jpg?v=1729887043"},{"product_id":"macrene-actives-gift-card","title":"DR. MACRENE actives Gift Card","description":"\u003cp\u003eShopping for someone but not sure what to give them? Give them the gift of choice with a DR. MACRENE\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eactives\u003c\/em\u003e gift card.\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003eGift cards are delivered by email and contain instructions to redeem at checkout. Our gift cards have no additional processing fees.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u003cmeta charset=\"utf-8\"\u003eEnjoy and best wishes from the DR. MACRENE \u003cem\u003eactives\u003c\/em\u003e team!\u003c\/span\u003e\u003c\/p\u003e","brand":"Macrene Actives","offers":[{"title":"$150.00","offer_id":43576815419633,"sku":"","price":150.0,"currency_code":"USD","in_stock":true},{"title":"$200.00","offer_id":43576816894193,"sku":"","price":200.0,"currency_code":"USD","in_stock":true},{"title":"$250.00","offer_id":43576816926961,"sku":"","price":250.0,"currency_code":"USD","in_stock":true},{"title":"$300.00","offer_id":43576816959729,"sku":"","price":300.0,"currency_code":"USD","in_stock":true},{"title":"$350.00","offer_id":43539226558705,"sku":null,"price":350.0,"currency_code":"USD","in_stock":true},{"title":"$400.00","offer_id":43576816992497,"sku":"","price":400.0,"currency_code":"USD","in_stock":true},{"title":"$450.00","offer_id":43576817025265,"sku":"","price":450.0,"currency_code":"USD","in_stock":true},{"title":"$500.00","offer_id":43539226624241,"sku":"","price":500.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/dr-macrene-actives-skincare-gift-card.png?v=1766067457"},{"product_id":"macrene-actives-skyros-high-performance-body-cream","title":"High Performance Body Cream","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e38 actives in a clean, vegan, fragrance-free, Grecian botanical-based cream formula scientifically proven and dermatologist tested to help reduce the appearance of fine lines and wrinkles, brighten and beautify the skin of the body.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe clean dermatologic formulas contained in \u003cmeta charset=\"utf-8\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSKYROS\u003c\/span\u003e target wrinkles, elasticity, and skin blotchiness by being the first to harness the medicinal power of Grecian island botanicals. Used for thousands of years by the Greeks, the founders of medicine dating back to Aesclepius, organic extracts of Wild Eλιά (Olive) Leaf, Pόδι (Pomegranate), Mελισσόχορτο (Lemon Balm) and Λουίζα (Verbena), help revive and rejuvenate the skin of the body. Brightening while helping reduce fine lines and wrinkles, \u003cmeta charset=\"utf-8\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSKYROS\u003c\/span\u003e body line is the first luxury Greek skincare to deliver unique botanicals, peptides, moisturizers and radiance boosters for your body skin’s total health.\u003c\/p\u003e\n\u003cblockquote\u003e\u003c\/blockquote\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":43597677101297,"sku":"536","price":145.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-body-cream-1.jpg?v=1729842577"},{"product_id":"high-performance-body-lotion","title":"High Performance Body Lotion","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003c\/span\u003e38 actives in a clean, vegan, fragrance-free, Grecian botanical-based lotion formula scientifically proven and dermatologist tested to help reduce the appearance of fine lines and wrinkles, brighten and beautify the skin of the body. \u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe clean dermatologic formulas contained in SKYROS target wrinkles, elasticity, and skin blotchiness by being the first to harness the medicinal power of Grecian island botanicals. Used for thousands of years by the Greeks, the founders of medicine dating back to Aesclepius, organic extracts of Wild Eλιά (Olive) Leaf, Pόδι (Pomegranate), Mελισσόχορτο (Lemon Balm) and Λουίζα (Verbena), help revive and rejuvenate the skin of the body. Brightening while helping reduce fine lines and wrinkles, SKYROS body line is the first luxury Greek skincare to deliver unique botanicals, peptides, moisturizers and radiance boosters for your body skin’s total health.\u003c\/p\u003e\n\u003cblockquote\u003e\u003c\/blockquote\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":43603682328817,"sku":"535","price":95.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-body-lotion-1.jpg?v=1729886290"},{"product_id":"skin-earth-high-performance-face-cream-sample-2ml","title":"Skin + Earth: High Performance Face Cream Sachet","description":"","brand":"Macrene Actives","offers":[{"title":"Default Title","offer_id":43880686452977,"sku":"412","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/Macrene_Sephora_Sample.jpg?v=1745854576"},{"product_id":"skin-earth-high-performance-eye-cream-sample-2ml","title":"Skin + Earth: High Performance Eye Cream Sachet","description":"","brand":"Macrene Actives","offers":[{"title":"Default Title","offer_id":43880691564785,"sku":"415","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/MacreneActivesHighPerformanceEyeCream.jpg?v=1746034243"},{"product_id":"four-facial-packages-luxe-facial-erase-time","title":"Facial Package Luxe Facial: Erase Time","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e \u003cmeta charset=\"utf-8\"\u003e\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe most effective non-invasive treatment for an instant skin transformation. The dermatologist-scientist’s opulent, plant-based formulas of DR. MACRENE actives    hydrate, deeply moisturize and help reduce the appearance of fine lines, blotches and wrinkles in the skin while providing healthy nutrients to replenish and rejuvenate. Every session of this highly specialized treatment triggers collagen and elastin production for immediately visible results and cumulative benefits over time. The combination of the Radiofrequency and microcurrent addresses major skin concerns like fine lines and wrinkles, sagging skin, pigmentation, acne, and scarring. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eAnd finally, the Oxygen Treatment will plump the skin, nourishing with clean active MACRENE actives sourced from medicinal botanicals and marine plants.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBest For: All skin types, especially mature skin\u003cbr data-mce-fragment=\"1\"\u003eExpected Results: A tighter and smoother complexion, reduced fine lines and wrinkles, lifted and toned contour, accumulation of collagen.\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44049346101489,"sku":"","price":1615.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44049346134257,"sku":"","price":2280.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/IMG_6999.jpg?v=1770515309"},{"product_id":"four-facial-package-men-s-facial","title":"Facial Package Men’s Facial","description":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp data-mce-fragment=\"1\"\u003eLong gone are the days of beauty treatments only being for women, because, everyone loves being pampered once in a while! And obviously there’s the added bonus of having healthy skin. We focus on problems some men may commonly deal with, such as razor burns, clogged pores, ingrown hairs, skin dullness and sensitivity. It’s also relaxing!\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThis facial tones, polishes and rejuvenates your skin. Following gentle ultrasonic cleansing and extractions, the face is massaged with the Gua Sha, which boosts lymphatic drainage, decreases puffiness, increases lift and contour of the face muscles.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe LED light therapy applied over MACRENE actives High Performance Treatment Serum will strengthen the skin and improve overall complexion. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eConcluded with indulgent face, neck and shoulder massage this facial will give you a truly blissful experience. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBest For: All skin types.\u003cbr data-mce-fragment=\"1\"\u003eExpected Results: \u003c\/p\u003e\n\u003cul data-mce-fragment=\"1\"\u003e\n\u003cli data-mce-fragment=\"1\"\u003eSoothed skin (particularly in the areas you shave)\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eUnclogged pores\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eHydration\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eReleased tension\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eToned complexion\u003c\/li\u003e\n\u003cli data-mce-fragment=\"1\"\u003eRevitalized mind.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eNote: If you would like to shave, make sure you do it the day before. If you shave on the day of your facial you may be more prone to irritation. \u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44050664915185,"sku":"","price":850.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44050664947953,"sku":"","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/A58558DC-D84B-474F-BBE2-FADEFC654890_19f260b9-304b-4a98-b397-51b4d741d6c2.webp?v=1699456834"},{"product_id":"four-facial-packages-rejuvenating-facial","title":"Facial Package Rejuvenating Facial","description":"\u003cp data-mce-fragment=\"1\"\u003eDedicated to improving skin health and appearance. This transformative facial tones, polishes and rejuvenates your skin. Following our gentle ultrasonic cleansing and extractions, the signature facial massage will ease tension and speed up healing process in skin.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eThe LED light therapy applied over MACRENE actives High Performance Treatment Serum will strengthen the skin and improve overall complexion. Added benefit comes from the Gua Sha massage and a special Facial Brush, that boost lymphatic drainage, decreases puffiness, increases lift and contour of the face muscles.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBest For: All skin types. Acne-prone skin.\u003cbr data-mce-fragment=\"1\"\u003eExpected Results: released tension, toned complexion and revitalized mind. \u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44050665177329,"sku":"","price":850.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44050665210097,"sku":"","price":1200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/DSC04047.jpg?v=1770515239"},{"product_id":"four-facial-package-ultimate-lift-facial","title":"Facial Package Ultimate Lift Facial","description":"\u003cp\u003eBrighter, healthier and lifted skin that you’ll love!\u003c\/p\u003e\n\u003cp\u003eRe-sculpt your appearance and achieve a youthful luminescence with this age defying treatment. This complete lifting facial with micronized currents works with the body’s bioelectrical waves, re-educating muscle tissue to tone and lift with visible results.\u003c\/p\u003e\n\u003cp\u003eLED Light Therapy is applied to rejuvenate and balance the skin, while the supercharged and powerfully effective plant and sea-sourced MACRENE actives formulas hydrate, smooth and brighten your skin.\u003c\/p\u003e\n\u003cp\u003eInvigorating facial massage, acupressure techniques, and lymphatic drainage will speed up circulation and bring more oxygen to your skin tissue.\u003c\/p\u003e\n\u003cp\u003eBest For: All skin types, especially overworked or mature skin.\u003cbr\u003eExpected Results: Tighter and smoother complexion, lifted and toned contour, stimulated collagen production and the healing process. \u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44049342628081,"sku":"","price":1275.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44049342660849,"sku":"","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/IMG_7020.jpg?v=1770515177"},{"product_id":"four-facial-package-signature-macrene-actives-facial","title":"Facial Package Signature Dr. Macrene Facial","description":"\u003cp data-mce-fragment=\"1\"\u003eThe DR. MACRENE actives dermatologic grade facial targets elasticity and reverses sun damage, firms, plumps, and evens out skin tone on the face, neck and décolletage, brightening brown spots and reviving skin for a supple, hydrated feel with her proprietary technologies. At its core, the first luxury skincare to deliver the medicinal properties of Greece cultivated over thousands of years. Expertly formulated by the renowned Clinical Dermatologist, Scientist, and Clean Beauty Authority™, Dr. Macrene Alexiades MD PhD. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eIn this facial, a stream of high-pressurized oxygen infused with  medicinal MACRENE actives serum is gently applied to the face and décollatage to soothe and restore.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOur signature lifting facial technique and lymphatic drainage will further improve skin texture, tone, elasticity by stimulating optimal circulation and sculpting the muscles of the face.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eExtended hand, arm and shoulder massage allows for luxurious pampering and rejuvenating experience during our LED light treatment, that stimulates collagen production and restores skin. Also ideal prior special occasions. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBest For: All skin types especially sensitive, dry skin.\u003cbr data-mce-fragment=\"1\"\u003eExpected Results: Toned complexion, reduced fine lines and wrinkles, improved hydration, clarity, plumping and glow. \u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44049344692465,"sku":"","price":1190.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44049344725233,"sku":"","price":1680.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/IMG_223831_0_3_ma.jpg?v=1770515022"},{"product_id":"facial-package-healing-teen-facial-55-minutes","title":"Facial Package Acne Facial","description":"\u003cp\u003e \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eUncover the importance of good skincare habits with our purifying facial, which is designed to specifically address breakouts and clean pores. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOur healing purifying facial begins with deep cleansing and gentle extractions. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eA soothing LED light will help reduce inflammation and redness while balancing the skin. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eDR. MACRENE actives skincare is clean, oil free, plant based, vegan, gluten-free and non-GMO.  No Parabens, plastics, Phthalates, Sulfates, Acrylates, Glycols, or fragrance. Our products will safely enhance the results of the facial. \u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eOur therapist will provide gentle and personal guidance for an effective at-home regime using our non-toxic skincare.\u003c\/p\u003e\n\u003cp data-mce-fragment=\"1\"\u003eBest For: Acne-prone skin. Teenage skin.\u003cbr data-mce-fragment=\"1\"\u003eExpected Results: Clearer and more refined skin\u003cbr data-mce-fragment=\"1\"\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"4 Facial Package","offer_id":44050664292593,"sku":"","price":816.0,"currency_code":"USD","in_stock":true},{"title":"6 Facial Package","offer_id":44050664325361,"sku":"","price":1152.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/IMG_7021.jpg?v=1770514240"},{"product_id":"high-performance-cleanser-sachet-new","title":"High Performance Cleanser Sachet NEW","description":"","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":44814553284849,"sku":"429","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ScreenShot2020-09-12at6.30.52PM.png?v=1714485939"},{"product_id":"chria-tinted-lip-filler","title":"High Performance Tinted Lip Filler — Chria Collection","description":"\u003cp\u003e\u003cstrong\u003eHigh Performance Tinted Lip Filler — Chria Collection\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe first lip color engineered to perform like a dermatologist's treatment.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eBuildable natural pigment — clean enough to eat — with a 20+ active treatment complex clinically designed to replicate the volumizing, smoothing, and protective effects of injectable lip filler. No needle required.\u003c\/p\u003e\n\u003cp\u003eOne swipe → sheer, natural color | Layered → rich, buildable pigment | Every wear → active treatment\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eKey Actives\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePeptides\u003c\/strong\u003e — Signal collagen and elastin production to visibly reduce lip fine lines and restore structural plumpness over time.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMicro-encapsulated hyaluronic acids\u003c\/strong\u003e — Encapsulation drives deeper penetration and sustained hydration versus conventional HA — moisture drawn in, not just layered on.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCeramides\u003c\/strong\u003e — Restore and reinforce the lip's natural moisture barrier, preventing water loss and chronic dryness.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e20 therapeutic antioxidants \u0026amp; organic plant oils\u003c\/strong\u003e — Neutralize environmental stressors, UV-induced oxidative damage, and inflammation that accelerate lip aging.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eThe Science Behind the Color\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eMost lip colors stop at the surface. Chria works beneath it.\u003c\/p\u003e\n\u003cp\u003eDr. Alexiades formulated each shade with over 20 bioactive ingredients — the same categories she reaches for in clinical practice — precisely dosed and micro-encapsulated for maximum delivery and stability. Chria (Greek for \u003cem\u003ehue\u003c\/em\u003e) was developed after decades of treating patients seeking the results of lip filler without the needle. The answer was not a better lipstick. It was a complete reimagining of what lip color could do.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhy Clean Pigment Matters\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eConventional lip colors rely on synthetic dyes and heavy metal-based pigments — ingredients applied to a mucous membrane that are inevitably ingested. Dr. Alexiades replaced every one with natural plant pigments safe enough to eat, without compromising color payoff or longevity.\u003c\/p\u003e\n\u003cp\u003eThis is not a marketing claim. It is a formulation standard set by a physician who understood exactly what was going into her patients' lips.\u003c\/p\u003e\n\u003chr\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Softer, more hydrated lips and a natural flush of buildable color.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Visibly reduced fine lines, improved lip definition, and sustained plumpness — without injection.\u003c\/p\u003e\n\u003chr\u003e","brand":"MACRENE actives","offers":[{"title":"Nude","offer_id":45376122814705,"sku":"440","price":65.0,"currency_code":"USD","in_stock":true},{"title":"Berry","offer_id":45376122847473,"sku":"441","price":65.0,"currency_code":"USD","in_stock":true},{"title":"Red","offer_id":45376122880241,"sku":"442","price":65.0,"currency_code":"USD","in_stock":true},{"title":"Pink","offer_id":45376122913009,"sku":"443","price":65.0,"currency_code":"USD","in_stock":true},{"title":"Clear","offer_id":45376122945777,"sku":"444","price":65.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/SG-MacreneActives-PDPs-NUDE_shadecolor.jpg?v=1757689236"},{"product_id":"high-performance-tinted-moisturizer-sachet","title":"High Performance Tinted Moisturizer Sachet","description":"","brand":"MACRENE actives","offers":[{"title":"Light","offer_id":45529876988145,"sku":"432","price":0.0,"currency_code":"USD","in_stock":true},{"title":"Light-Medium","offer_id":45529877020913,"sku":"435","price":0.0,"currency_code":"USD","in_stock":true},{"title":"Medium","offer_id":45529877053681,"sku":"433","price":0.0,"currency_code":"USD","in_stock":true},{"title":"Medium-Deep","offer_id":45529877086449,"sku":"436","price":0.0,"currency_code":"USD","in_stock":true},{"title":"Deep","offer_id":45529877119217,"sku":"434","price":0.0,"currency_code":"USD","in_stock":true},{"title":"Extra Deep","offer_id":45529877151985,"sku":"437","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/DEEP_SKU434.jpg?v=1726754192"},{"product_id":"build-your-own-skincare-bundle","title":"Build Your Own Skincare Bundle","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eYour skin, your way. Build your custom routine with Dr. Macrene’s scientifically advanced formulas. Receive 15% off when you bundle 3-5 products.\u003c\/p\u003e\n\u003cp\u003e*\u003cem\u003eOnly select products are eligible for this offer.\u003c\/em\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":45864179958001,"sku":"","price":100.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/BYOBundle_Thumbnail_4.png?v=1736803178"},{"product_id":"high-performance-eye-mask","title":"High Performance Eye Mask","description":"\u003cp\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003e\u003cstrong data-start=\"233\" data-end=\"271\"\u003eComplete Skincare for the Eye Area\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eFormulated by dermatologist-scientist \u003cstrong data-start=\"311\" data-end=\"326\"\u003eDr. Macrene\u003c\/strong\u003e, this advanced biocellulose eye treatment is designed to visibly restore and refine the delicate eye area.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eEach patch delivers a concentrated infusion of \u003cstrong data-start=\"482\" data-end=\"638\"\u003epeptides, microencapsulated hyaluronic acid, DNA-supporting enzymes, antioxidants, brighteners, plant-derived caffeine, and microbiome-balancing actives\u003c\/strong\u003e to improve hydration, firmness, and luminosity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003ePowered by the patented \u003cstrong data-start=\"712\" data-end=\"752\"\u003eMA37™ multi-targeted delivery system\u003c\/strong\u003e, it enhances absorption and performance while maintaining skin comfort.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eDeveloped through decades of dermatologic and genetics research, this treatment improves overall skin quality around the eyes with precision and care.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"978\" data-end=\"981\"\u003e\n\u003ch3 data-start=\"983\" data-end=\"1003\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003e\u003cstrong data-start=\"987\" data-end=\"1003\"\u003eKey Benefits\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul data-start=\"1005\" data-end=\"1318\"\u003e\n\u003cli data-start=\"1005\" data-end=\"1063\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eVisibly reduces the look of puffiness and dark circles\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-start=\"1064\" data-end=\"1104\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eSmooths the appearance of fine lines\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-start=\"1105\" data-end=\"1161\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eFirms and improves elasticity with advanced peptides\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-start=\"1162\" data-end=\"1206\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eDeeply hydrates and replenishes moisture\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-start=\"1207\" data-end=\"1257\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eEnhances radiance and overall eye-area clarity\u003c\/span\u003e\u003c\/li\u003e\n\u003cli data-start=\"1258\" data-end=\"1318\" style=\"color: rgb(64, 64, 64);\"\u003e\u003cspan style=\"color: rgb(64, 64, 64);\"\u003eSupports skin resilience against environmental stressors\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"MACRENE actives","offers":[{"title":"Pack of 6","offer_id":46112061915377,"sku":"445","price":115.0,"currency_code":"USD","in_stock":true},{"title":"Single Sachet","offer_id":46112061882609,"sku":"446","price":20.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/ma-cleanser-eco-2.0oz-1-EDITED.jpg?v=1746960572"},{"product_id":"healthy-skin-essentials-set","title":"Healthy Skin Essentials Set","description":"\u003cp\u003eElevate your holiday ritual with this limited-edition \u003cstrong data-start=\"175\" data-end=\"207\"\u003eHealthy Skin Essentials Set\u003c\/strong\u003e, a complete regimen designed to cleanse, restore, and revitalize skin. Featuring the award-winning \u003cstrong data-start=\"307\" data-end=\"338\"\u003eHigh Performance Face Cream\u003c\/strong\u003e, moisture-boosting \u003cstrong data-start=\"358\" data-end=\"384\"\u003eHigh Performance Face Serum\u003c\/strong\u003e, and antioxidant-rich \u003cstrong data-start=\"407\" data-end=\"436\"\u003eHigh Performance Cleanser\u003c\/strong\u003e, each formula is powered by Dr. Macrene’s proprietary blend of plant-derived active ingredients to hydrate, firm, brighten, and smooth the appearance of fine lines and wrinkles. The set also includes a \u003cstrong data-start=\"629\" data-end=\"673\"\u003edeluxe organic hemp and cotton zip pouch\u003c\/strong\u003e, sustainably designed for beauty on the go. A $490 value, this holiday-exclusive collection is where science meets nature, making radiant, youthful-looking skin the ultimate gift.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIncludes:\u003c\/strong\u003e \u003cbr\u003eHigh Performance Face Cream 1 oz.\u003cbr\u003eHigh Performance Cleanser 2 oz. \u003cbr\u003eHigh Performance Face Serum 0.5 oz. \u003cbr\u003eOrganic Hemp \u0026amp; Cotton Zip Pouch\u003cbr\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":46979799187697,"sku":"1003","price":345.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/macrene-actives-healthy-skin-essentials-set.jpg?v=1759236917"},{"product_id":"dr-macrene-actives-discovery-set","title":"The Discovery Set","description":"\u003cp\u003e\u003cstrong\u003eDiscovery Set\u003c\/strong\u003e \u003cem\u003eFormulated by Dr. Macrene Alexiades, MD, PhD · Dual Board-Certified Dermatologist \u0026amp; Research Scientist\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFive clinically-formulated essentials. One complete introduction to the science of better skin.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe Discovery Set brings together Dr. Alexiades's most foundational treatments — from lips to eyes — in one curated collection. Each product is built on the same 20+ active philosophy that defines the DR. MACRENE actives line: no filler ingredients, no compromises, every formula carrying a full clinical payload.\u003c\/p\u003e\n\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cem\u003eA $370 value at $295 ($75 courtesy)\u003c\/em\u003e, presented in an organic hemp and cotton zip pouch.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eWhat's Inside\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Performance Cleanser — 2 oz.\u003c\/strong\u003e An antioxidant-rich cleanse that removes impurities without stripping the skin's natural barrier. The clinical starting point for every DR. MACRENE actives routine.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Performance Face Serum — 0.5 oz.\u003c\/strong\u003e A lifting, brightening concentrate formulated to visibly firm and luminize. Delivers active ingredients at the concentration and depth a dermatologist would specify.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Performance Lip Filler — Clear, 0.2 oz.\u003c\/strong\u003e The injection-free lip treatment. Peptides, micro-encapsulated hyaluronic acids, ceramides, and 20 therapeutic antioxidants work with every wear to plump, smooth, and protect.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHigh Performance Eye Masks — 2 single masks\u003c\/strong\u003e Dr. Alexiades's newest innovation for the most delicate and revealing area of the face. Powered by peptides, hyaluronic acid, antioxidants, and brighteners to visibly refresh, depuff, and restore a more youthful contour — results you will see immediately.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eOrganic Hemp \u0026amp; Cotton Zip Pouch\u003c\/strong\u003e A reusable, sustainably sourced travel pouch. Curated to keep your routine together, at home or away.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eWhat You Will See\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eImmediately: Brighter, more refreshed skin and visibly smoother, more hydrated lips and eye area.\u003c\/p\u003e\n\u003cp\u003eWith regular use: Visibly firmer skin, improved luminosity, reduced fine lines, and sustained lip and eye area plumpness — without injection.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eThe DR. MACRENE actives Difference\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eEvery product in this set was formulated by a physician who spent decades in clinical practice before creating a single formula. Where most skincare brands work with cosmetic chemists to approximate results, Dr. Alexiades built each product around the active ingredients she prescribed — then engineered them to penetrate, perform, and last. This is where science meets nature, and where a beginner's introduction to skincare becomes a genuinely clinical one.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003cp\u003e\u003cstrong\u003eIncludes\u003c\/strong\u003e High Performance Cleanser 2 oz. · High Performance Face Serum 0.5 oz. · High Performance Lip Filler Clear 0.2 oz. · High Performance Eye Mask Single x2 · Organic Hemp \u0026amp; Cotton Zip Pouch\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA $370 value at $295 ($75 courtesy).\u003c\/em\u003e\u003c\/p\u003e","brand":"MACRENE actives","offers":[{"title":"Default Title","offer_id":46979819372785,"sku":"1004","price":295.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0365\/5549\/files\/macrene-actives-discovery-skincare-set.jpg?v=1759261962"}],"url":"https:\/\/macreneactives.com\/collections\/all.oembed","provider":"DR. MACRENE actives","version":"1.0","type":"link"}